Lingzhi or reishi medicinal mushroom, ganoderma lucidum (Agaricomycetes) ameliorates spatial learning and memory deficits in rats with hypercholesterolemia and alzheimer’s disease

Mohammad Azizur Rahman, Shahdat Hossain, Noorlidah Abdullah, Norhaniza Aminudin

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1 Citation (Scopus)


Hypercholesterolemia has been implicated as one of the pathomechanistic factors of Alzheimer’s disease (AD), the most common neurodegenerative disorder affecting memory and learning abilities. In the present study, ameliorative effect of hot water extract (HWE) of mushroom Ganoderma lucidum to the memory and learning related behavioral performance of hypercholesterolemic and AD rats was investigated using Morris water maze (MWM). Male Wistar rats were randomly grouped into control, extract fed control, hypercholesterolemic, extract fed hypercholesterolemic, AD, and extract fed AD groups, each group containing 8 animals. Hypercholesterolemia was induced in rats by adding 1% cholesterol and 1% cholic acid with the basal diet of the respective group. Alzheimer’s disease model rats were prepared through infusion of amyloid β(1-42) to the right ventricle. Memory and learning related performance of all the rats was tested for 6 consecutive days that included time taken to reach the submerged platform (sec) and distance traveled (m). G. lucidum HWE fed rats took less time and traveled less distance to find the submerged platform, which indicates the spatial learning and memory related behavioral amelioration of the extract fed rats compared with their nonfed counterparts. Thus, usage of G. lucidum seems promising in withstanding hypercholesterolemia-induced Alzheimer’s disease pathogenesis.

Original languageEnglish
Pages (from-to)93-103
Number of pages11
JournalInternational Journal of Medicinal Mushrooms
Issue number1
Publication statusPublished - 1 Jan 2020



  • Alzheimer’s disease
  • Amyloid beta
  • Ganoderma lucidum
  • Hypercholesterolemia
  • Medicinal mushrooms
  • Morris water maze
  • Oxidative stress

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery

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