Linezolid-resistant enterococci in Greece: Epidemiological characteristics

Iris Spiliopoulou, Anthi Damani, Vassiliki Chini, Loukia Zerva, Fevronia Kolonitsiou, Evangelos D. Anastassiou, Efthimia Petinaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: 14 linezolid-resistant enterococci (6 Enterococcus faecium and 8 Enterococcus faecalis) collected during 2009 from patients hospitalized in intensive care units of different Greek hospitals were investigated. Methods: The mechanism of resistance to linezolid was determined by sequencing analysis of the domain V of 23S rDNA, while the clonal relatedness was defined by pulsed-field gel electrophoresis and multilocus sequence typing. Results: All linezolid-resistant enterococci carried the G2576T mutation. E. faecium belonged to the international epidemic clones ST16, ST17, ST203 and ST65, while all E. faecalis strains belonged to the ST28 clone. Conclusions: The spread of common linezolid-resistant enterococcal clones in intensive care units located in different areas of Greece emphasizes the importance of application of infection control measures to prevent the spread of such strains.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalChemotherapy
Volume57
Issue number3
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

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Keywords

  • Clones
  • Enterococci
  • G2576T mutation
  • Linezolid resistance

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery

Cite this

Spiliopoulou, I., Damani, A., Chini, V., Zerva, L., Kolonitsiou, F., Anastassiou, E. D., & Petinaki, E. (2011). Linezolid-resistant enterococci in Greece: Epidemiological characteristics. Chemotherapy, 57(3), 181-185. https://doi.org/10.1159/000326444