Leukocyte telomere length, breast cancer risk in the offspring

The relations with father's age at birth

Konstantin G. Arbeev, Steven Hunt, Masayuki Kimura, Abraham Aviv, Anatoliy I. Yashin

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring of older fathers. Longer telomeres might increase cancer risk. We examined the relation of father's age at the birth of the offspring (FAB) with LTL in the offspring in 2177 participants of the Family Heart Study and the probability of developing breast cancer in 1405 women from the Framingham Heart Study (offspring cohort). For each year of increase in FAB (adjusted for mother's age at birth), LTLs in the daughters and sons were longer by 19.4. bp and 12.2. bp, respectively (p< 0.0001). Daughters of older fathers were less likely to stay free of breast cancer compared to daughters of younger fathers in empirical (p= 0.014) and Cox regression analyses (p= 0.0012) adjusted for relevant covariates. We conclude that older fathers endow their offspring with a longer LTL and their daughters with increased susceptibility to breast cancer. These independent observations cannot provide evidence for a causal relationship, mediated by telomere length, between FAB and increased breast cancer risk in daughters. However, with couples delaying having children in today's society, studies exploring the LTL association with increased breast cancer risk in daughters of older fathers might be timely and relevant.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalMechanisms of Ageing and Development
Volume132
Issue number4
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

Fingerprint

Telomere
Nuclear Family
Fathers
Leukocytes
Parturition
Breast Neoplasms
Cohort Studies
Regression Analysis
Mothers
Neoplasms

Keywords

  • Breast cancer
  • Daughters
  • Father's age
  • Offspring
  • Telomeres

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

Cite this

Leukocyte telomere length, breast cancer risk in the offspring : The relations with father's age at birth. / Arbeev, Konstantin G.; Hunt, Steven; Kimura, Masayuki; Aviv, Abraham; Yashin, Anatoliy I.

In: Mechanisms of Ageing and Development, Vol. 132, No. 4, 04.2011, p. 149-153.

Research output: Contribution to journalArticle

Arbeev, Konstantin G. ; Hunt, Steven ; Kimura, Masayuki ; Aviv, Abraham ; Yashin, Anatoliy I. / Leukocyte telomere length, breast cancer risk in the offspring : The relations with father's age at birth. In: Mechanisms of Ageing and Development. 2011 ; Vol. 132, No. 4. pp. 149-153.
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