Leukocyte Telomere Length and Coronary Artery Calcium

Steven Hunt, Masayuki Kimura, Paul N. Hopkins, J. Jeffrey Carr, Gerardo Heiss, Michael A. Province, Abraham Aviv

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Patients with histories of myocardial infarction display shortened leukocyte telomere length (LTL), but conflicting findings have been reported on the relation between LTL and subclinical coronary artery atherosclerosis, as expressed by coronary artery calcium (CAC). The aim of this study was to examine the relation between LTL, measured by Southern blots, and CAC in 3,169 participants in the National Heart, Lung, and Blood Institute Family Heart Study. Participants consisted of 2,556 whites, 613 blacks, 1,790 women, and 1,379 men. The odds of having CAC ≥100 for the shortest LTL tertile versus the longest LTL tertile were 1.95 (95% confidence interval [CI] 1.28 to 3.16) in white men and 1.76 (95% CI 1.18 to 2.45) in white women, after adjusting for multiple covariates of CAC. The corresponding odds ratios for blacks were 1.53 (95% CI 0.67 to 3.50) and 0.87 (95% CI 0.37 to 2.00). Significance levels of tests for trend across LTL tertiles were p = 0.002 in white men, p = 0.006 in white women, p = 0.32 in black men, and p = 0.74 in black women. The associations, or lack of associations, were independent of C-reactive protein levels and other risk factors for CAC. As previously shown in other studies, whites displayed shorter LTLs than blacks (p <0.0001). In conclusion, the higher the coronary artery atherosclerotic burden in whites, the shorter the LTL. This LTL-atherosclerosis connection is not found in blacks. The mechanisms for the racial difference in LTL, CAC, and their interrelations do not seem to be related to inflammation and merit further research.

Original languageEnglish
Article number21114
Pages (from-to)214-218
Number of pages5
JournalAmerican Journal of Cardiology
Volume116
Issue number2
DOIs
Publication statusPublished - 15 Jul 2015

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Telomere
Coronary Vessels
Leukocytes
Calcium
Confidence Intervals
National Heart, Lung, and Blood Institute (U.S.)
Telomere Shortening
Southern Blotting
C-Reactive Protein
Coronary Artery Disease
Atherosclerosis
Odds Ratio
Myocardial Infarction
Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hunt, S., Kimura, M., Hopkins, P. N., Carr, J. J., Heiss, G., Province, M. A., & Aviv, A. (2015). Leukocyte Telomere Length and Coronary Artery Calcium. American Journal of Cardiology, 116(2), 214-218. [21114]. https://doi.org/10.1016/j.amjcard.2015.03.060

Leukocyte Telomere Length and Coronary Artery Calcium. / Hunt, Steven; Kimura, Masayuki; Hopkins, Paul N.; Carr, J. Jeffrey; Heiss, Gerardo; Province, Michael A.; Aviv, Abraham.

In: American Journal of Cardiology, Vol. 116, No. 2, 21114, 15.07.2015, p. 214-218.

Research output: Contribution to journalArticle

Hunt, S, Kimura, M, Hopkins, PN, Carr, JJ, Heiss, G, Province, MA & Aviv, A 2015, 'Leukocyte Telomere Length and Coronary Artery Calcium', American Journal of Cardiology, vol. 116, no. 2, 21114, pp. 214-218. https://doi.org/10.1016/j.amjcard.2015.03.060
Hunt S, Kimura M, Hopkins PN, Carr JJ, Heiss G, Province MA et al. Leukocyte Telomere Length and Coronary Artery Calcium. American Journal of Cardiology. 2015 Jul 15;116(2):214-218. 21114. https://doi.org/10.1016/j.amjcard.2015.03.060
Hunt, Steven ; Kimura, Masayuki ; Hopkins, Paul N. ; Carr, J. Jeffrey ; Heiss, Gerardo ; Province, Michael A. ; Aviv, Abraham. / Leukocyte Telomere Length and Coronary Artery Calcium. In: American Journal of Cardiology. 2015 ; Vol. 116, No. 2. pp. 214-218.
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