Lens shape and refractive index distribution in type 1 diabetes

Adnan, James M. Pope, Farshid Sepehrband, Marwan Suheimat, Pavan K. Verkicharla, Sanjeev Kasthurirangan, David A. Atchison

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PURPOSE. To compare lens dimensions and refractive index distributions in type 1 diabetes and age-matched control groups. METHODS. There were 17 participants with type 1 diabetes, consisting of two subgroups (7 young [23 ± 4 years] and 10 older [54 ± 4 years] participants), with 23 controls (13 young, 24 ± 4 years; 10 older, 55 ± 4 years). For each participant, one eye was tested with relaxed accommodation. A 3T clinical magnetic resonance imaging scanner was used to image the eye, employing a multiple spin echo (MSE) sequence to determine lens dimensions and refractive index profiles along the equatorial and axial directions. RESULTS. The diabetes group had significantly smaller lens equatorial diameters and larger lens axial thicknesses than the control group (diameter mean ± 95% confidence interval [CI]: diabetes group 8.65 ± 0.26 mm, control group 9.42 ± 0.18 mm; axial thickness: diabetes group 4.33 ± 0.30 mm, control group 3.80 ± 0.14 mm). These differences were also significant within each age group. The older group had significantly greater axial thickness than the young group (older group 4.35 ± 0.26 mm, young group 3.70 ± 0.25 mm). Center refractive indices of diabetes and control groups were not significantly different. There were some statistically significant differences between the refractive index fitting parameters of young and older groups, but not between diabetes and control groups of the same age. CONCLUSIONS. Smaller lens diameters occurred in the diabetes groups than in the age-matched control groups. Differences in refractive index distribution between persons with and without diabetes are too small to have important effects on instruments measuring axial thickness.

Original languageEnglish
Pages (from-to)4759-4766
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Issue number8
Publication statusPublished - 1 Jan 2015



  • Diabetes type 1
  • Equatorial diameter
  • Lens
  • Lens dimensions
  • Lens thickness
  • Ocular parameters
  • Refractive index distribution

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Adnan, Pope, J. M., Sepehrband, F., Suheimat, M., Verkicharla, P. K., Kasthurirangan, S., & Atchison, D. A. (2015). Lens shape and refractive index distribution in type 1 diabetes. Investigative Ophthalmology and Visual Science, 56(8), 4759-4766. https://doi.org/10.1167/iovs.15-16430