Learning biological networks via bootstrapping with optimized GO-based gene similarity

Ronald Taylor, Bob Baddeley, Antonio Sanfilippo, Rick Riensche, Marc Verhagen, Jason McDermott, Russ Jensen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microarray gene expression data provide a unique information resource for learning biological networks using "reverse engineering" methods. However, there are a variety of cases in which we know which genes are involved in a given pathology of interest, but we do not have enough experimental evidence to support the use of fully-supervised/reverse-engineering learning methods. Moreover, corroboration of the reverse engineered networks through independent means such as evidence from the biomedical literature is always desirable. In this paper, we explore a novel semi-supervised approach in which biological networks are learned from a reference list of genes and a partial set of links for these genes extracted automatically from PubMed abstracts, using a knowledge-driven bootstrapping algorithm. We show how new relevant links between genes can be iteratively derived using a gene similarity measure based on the Gene Ontology that is optimized on the input network at each iteration. An initial evaluation indicates the viability of the approach as an alternate or complementary technique to fully supervised methods.

Original languageEnglish
Title of host publication2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
Pages515-519
Number of pages5
DOIs
Publication statusPublished - 25 Oct 2010
Event2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010 - Niagara Falls, NY, United States
Duration: 2 Aug 20104 Aug 2010

Publication series

Name2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010

Conference

Conference2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
CountryUnited States
CityNiagara Falls, NY
Period2/8/104/8/10

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Keywords

  • Biological networks
  • Gene ontology
  • Network inference
  • Simulated annealing
  • Supervised machine learning

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Information Management

Cite this

Taylor, R., Baddeley, B., Sanfilippo, A., Riensche, R., Verhagen, M., McDermott, J., & Jensen, R. (2010). Learning biological networks via bootstrapping with optimized GO-based gene similarity. In 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010 (pp. 515-519). (2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010). https://doi.org/10.1145/1854776.1854875