Lead inhibits the voltage-activated calcium current of aplysia neurons

Dietrich Busselberg, Martyn L. Evans, Hinrich Rahmann, David O. Carpenter

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Lead is a potent and reversible inhibitor of the voltage-dependent calcium current of Aplysia neurons in a concentration range (1-1000 μM) similar to that which elicits toxic effects in man. The threshold for inhibition is 1 μM and the dissociation constant about 90 μM. The inhibition is due to reduction of the peak current amplitude, and not due to alteration of the voltage dependence of the activation or inactivation. The effect of lead is specific to the calcium current as the delayed rectifier potassium and the sodium currents are not affected by concentrations of lead (200 μM) which give near-maximal inhibition. The calcium current of Aplysia neurons appears similar to the current flowing through the mammalian l-type calcium channel. This suggests that inhibition of the investigated calcium channel may contribute to the toxic effects of lead in mammals.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalToxicology Letters
Volume51
Issue number1
DOIs
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Aplysia
Neurons
Calcium
Poisons
Electric potential
Calcium Channels
Mammals
Potassium
Sodium
Chemical activation
Lead

Keywords

  • Aplysia neurons
  • Calcium channel
  • Channel blocker
  • Lead poisoning

ASJC Scopus subject areas

  • Toxicology

Cite this

Lead inhibits the voltage-activated calcium current of aplysia neurons. / Busselberg, Dietrich; Evans, Martyn L.; Rahmann, Hinrich; Carpenter, David O.

In: Toxicology Letters, Vol. 51, No. 1, 1990, p. 51-57.

Research output: Contribution to journalArticle

Busselberg, Dietrich ; Evans, Martyn L. ; Rahmann, Hinrich ; Carpenter, David O. / Lead inhibits the voltage-activated calcium current of aplysia neurons. In: Toxicology Letters. 1990 ; Vol. 51, No. 1. pp. 51-57.
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