Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in Utah

Steven C. Hunt, Yuanpei Xin, Lily L. Wu, Paul N. Hopkins, Ted D. Adams

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Three polymorphisms of the glutamate decarboxylase 2 gene, which encodes the glutamic acid decarboxylase enzyme, have been associated with severe obesity in a large French cohort. One of these polymorphisms was shown to have functional consequences on promoter expression. Another polymorphism was associated with insulin levels and secretion. These associations were examined in 855 severely obese Utah subjects (mean BMI = 48 kg/m2) and a normal-weight and normoglycemic subset (N = 130, mean BMI = 22 kg/m2) of a random sample of the Utah population (N = 462). Comparisons of the normal-weight random group with the severely obese group did not result in significant genotype or allele frequency differences for any of the three polymorphisms, C61450A, T83897A, or A-243G (all p ≥ 0.18). Haplotypes were also not related to severe obesity (p = 0.10). None of the polymorphisms was significantly related to fasting glucose, insulin levels, or homeostasis model assessment insulin resistance or secretion indices. This study of normal-weight and severely obese subjects from Utah does not provide evidence for involvement of the three genotyped polymorphisms in the glutamate decarboxylase 2 gene with obesity or with insulin- and glucose-related measures associated with obesity.

Original languageEnglish
Pages (from-to)650-655
Number of pages6
JournalObesity
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 2006
Externally publishedYes

Fingerprint

Morbid Obesity
Insulin
Weights and Measures
Obesity
Genes
Glucose
Glutamate Decarboxylase
Gene Frequency
Haplotypes
Insulin Resistance
Fasting
Homeostasis
Genotype
Enzymes
Population
glutamate decarboxylase 2

Keywords

  • Association
  • Genetics
  • Glutamate decarboxylase 2 gene
  • Severe obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in Utah. / Hunt, Steven C.; Xin, Yuanpei; Wu, Lily L.; Hopkins, Paul N.; Adams, Ted D.

In: Obesity, Vol. 14, No. 4, 04.2006, p. 650-655.

Research output: Contribution to journalArticle

Hunt, Steven C. ; Xin, Yuanpei ; Wu, Lily L. ; Hopkins, Paul N. ; Adams, Ted D. / Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in Utah. In: Obesity. 2006 ; Vol. 14, No. 4. pp. 650-655.
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