Lack of association between human leukocyte antigen-E alleles and nasopharyngeal carcinoma in Tunisians

Elham Hassen, Randa Ghedira, Nahla Ghandri, Karim Farhat, Sallouha Gabbouj, Noureddine Bouaouina, Hamdi Abdelaziz, Abdelatif Nouri, Lotfi Chouchane

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Abstract

Nasopharyngeal carcinoma (NPC), a cancer with a remarkable geographical and worldwide ethnic distribution, has been strongly associated with human leukocyte antigen (HLA) class I genes. The presence of additional HLA risk factors has been suggested by several reports. In the present study, we analyzed the implication of HLA-E gene polymorphisms in NPC susceptibility in Tunisians, a population characterized by an intermediate incidence of NPC with specific clinical features. Peripheral blood DNA was obtained from 185 patients with NPC and 177 matched controls. Genotyping for three single-nucleotide polymorphisms, codon 83Gly/Arg, codon 157Arg/Gly, and codon 107Arg/Gly, was performed using the polymerase chain reaction method. The HLA-E*01:01 and HLA-E*01:03 were the only alleles found among Tunisians. The HLA-E*01:03 allele had a slight increase in patients with NPC (43%) compared with controls (37%), but the difference did not reach a statistical significance. Our results show the lack of association between HLA-E alleles and NPC in the Tunisian population. This is not in agreement with the previous studies, suggesting a potential implication of HLA-E gene polymorphisms in the susceptibility to NPC among populations with high-risk incidence. Our study further supports the dissimilarity of NPC between populations with different NPC incidence.

Original languageEnglish
Pages (from-to)603-609
Number of pages7
JournalDNA and Cell Biology
Volume30
Issue number8
DOIs
Publication statusPublished - 30 Aug 2011

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HLA Antigens
Alleles
Codon
Population
Incidence
MHC Class I Genes
Nasopharyngeal carcinoma
Genes
Single Nucleotide Polymorphism
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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Lack of association between human leukocyte antigen-E alleles and nasopharyngeal carcinoma in Tunisians. / Hassen, Elham; Ghedira, Randa; Ghandri, Nahla; Farhat, Karim; Gabbouj, Sallouha; Bouaouina, Noureddine; Abdelaziz, Hamdi; Nouri, Abdelatif; Chouchane, Lotfi.

In: DNA and Cell Biology, Vol. 30, No. 8, 30.08.2011, p. 603-609.

Research output: Contribution to journalArticle

Hassen, E, Ghedira, R, Ghandri, N, Farhat, K, Gabbouj, S, Bouaouina, N, Abdelaziz, H, Nouri, A & Chouchane, L 2011, 'Lack of association between human leukocyte antigen-E alleles and nasopharyngeal carcinoma in Tunisians', DNA and Cell Biology, vol. 30, no. 8, pp. 603-609. https://doi.org/10.1089/dna.2010.1140
Hassen, Elham ; Ghedira, Randa ; Ghandri, Nahla ; Farhat, Karim ; Gabbouj, Sallouha ; Bouaouina, Noureddine ; Abdelaziz, Hamdi ; Nouri, Abdelatif ; Chouchane, Lotfi. / Lack of association between human leukocyte antigen-E alleles and nasopharyngeal carcinoma in Tunisians. In: DNA and Cell Biology. 2011 ; Vol. 30, No. 8. pp. 603-609.
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