Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques

Ussama M. Abdel-Motal, Jacqueline Gillis, Kelledy Manson, Michael Wyand, David Montefiori, Kelly Stefano-Cole, Ronald C. Montelaro, John D. Altman, R. Paul Johnson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The ability of memory T cells to mount a recall response plays a key role in the ability of vaccinated animals to contain viral challenge. In this study, we intensively monitored the expansion of SIV Gag-specific CD8+ T cells in peripheral blood and tissues of rhesus macaques vaccinated with the attenuated strain SIVmac239Δ3 and challenged with the pathogenic viruses SIVmac239 or SIVsmE660. Although all vaccinated animals were infected with challenge virus, peak levels of plasma viremia in vaccinees were decreased by 1.5 to 2 logs as compared with naive controls. Decreased levels of plasma viremia in vaccinated animals were evident as early as 7 days post-challenge, well before the expansion of SIV-specific CD8+ T cells. Expansion of SIV-specific CD8+ T cells was not observed in peripheral blood or tissues until at least 14 days after infection and did not occur in most animals until after the initial peak of viral replication. The observation that expansion of SIV-specific CD8+ T cells is delayed until 7 days or more after initial detection of viremia highlights fundamental limitations in the ability of lentivirus-specific CD8+ T cells to mediate protection against challenge.

Original languageEnglish
Pages (from-to)226-238
Number of pages13
JournalVirology
Volume333
Issue number2
DOIs
Publication statusPublished - 15 Mar 2005

Keywords

  • AIDS vaccine
  • Cytotoxic T lymphocytes
  • Live attenuated SIV vaccine
  • Mucosal immunity
  • Neutralizing antibodies
  • Nonhuman primates
  • Protective immunity
  • Simian immunodeficiency virus

ASJC Scopus subject areas

  • Virology

Fingerprint Dive into the research topics of 'Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques'. Together they form a unique fingerprint.

  • Cite this

    Abdel-Motal, U. M., Gillis, J., Manson, K., Wyand, M., Montefiori, D., Stefano-Cole, K., Montelaro, R. C., Altman, J. D., & Johnson, R. P. (2005). Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques. Virology, 333(2), 226-238. https://doi.org/10.1016/j.virol.2004.12.030