Key associations for hepatitis C virus genotypes in the Middle East and North Africa

Sarwat Mahmud, Hiam S. Chemaitelly, Silva P. Kouyoumjian, Zaina Al Kanaani, Laith J. Abu-Raddad

Research output: Contribution to journalArticle

Abstract

This study aimed to investigate the epidemiology of hepatitis C virus (HCV) genotypes in the Middle East and North Africa (MENA) through an analytical and quantitative meta-regression methodology. For the most common genotypes 1, 3, and 4, country/subregion explained more than 77% of the variation in the distribution of each genotype. Genotype 1 was common across MENA, and was more present in high-risk clinical populations than in the general population. Genotype 3 was much more present in Afghanistan, Iran, and Pakistan than the rest of countries, and was associated with transmission through injecting drug use. Genotype 4 was broadly disseminated in Egypt in all populations, with overall limited presence elsewhere. While genotype 2 was more present in high-risk clinical populations and people who inject drugs, most of the variation in its distribution remained unexplained. Genotypes 5, 6, and 7 had low or no presence in MENA, limiting the epidemiological inferences that could be drawn. To sum up, geography is the principal determinant of HCV genotype distribution. Genotype 1 is associated with transmission through high-risk clinical procedures, while genotype 3 is associated with injecting drug use. These findings demonstrate the power of such analytical approach, which if extended to other regions and globally, can yield relevant epidemiological inferences.

Original languageEnglish
JournalJournal of Medical Virology
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Fingerprint

Northern Africa
Eastern Africa
Middle East
Hepacivirus
Genotype
Population
Pharmaceutical Preparations
Afghanistan
Geography
Egypt
Pakistan
Iran
Epidemiology

Keywords

  • genotype
  • HCV
  • meta-regression
  • Middle East and North Africa
  • transmission

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Mahmud, S., Chemaitelly, H. S., Kouyoumjian, S. P., Al Kanaani, Z., & Abu-Raddad, L. J. (Accepted/In press). Key associations for hepatitis C virus genotypes in the Middle East and North Africa. Journal of Medical Virology. https://doi.org/10.1002/jmv.25614

Key associations for hepatitis C virus genotypes in the Middle East and North Africa. / Mahmud, Sarwat; Chemaitelly, Hiam S.; Kouyoumjian, Silva P.; Al Kanaani, Zaina; Abu-Raddad, Laith J.

In: Journal of Medical Virology, 01.01.2019.

Research output: Contribution to journalArticle

Mahmud, Sarwat ; Chemaitelly, Hiam S. ; Kouyoumjian, Silva P. ; Al Kanaani, Zaina ; Abu-Raddad, Laith J. / Key associations for hepatitis C virus genotypes in the Middle East and North Africa. In: Journal of Medical Virology. 2019.
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