Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.

B. J. Wainwright, P. J. Scambler, P. Stanier, E. K. Watson, G. Bell, C. Wicking, Xavier P. Estivill, M. Courtney, A. Boue, P. S. Pedersen

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

An expressed gene sequence which was identified by the isolation of a methylation free CpG island from human chromosome 7 has been cloned from a human lung cDNA library. The deduced protein sequence contains 360 amino acids and has several features of a secreted protein; it is cysteine rich with a signal peptide sequence and two potential asn-linked glycosylation sites. The protein sequence shows marked similarity with human and murine int-1 and their Drosophila homolog wingless (Dint-1). This human int-1 related protein, int-1 and Dint-1 have diverse patterns of expression, but the inferred structural similarities suggest that some of the functional characteristics of these proteins may be shared.

Original languageEnglish
Pages (from-to)1743-1748
Number of pages6
JournalEMBO Journal
Volume7
Issue number6
Publication statusPublished - Jun 1988
Externally publishedYes

Fingerprint

Drosophila
Genes
Proteins
Glycosylation
CpG Islands
Chromosomes, Human, Pair 7
Methylation
Human Chromosomes
Chromosomes
Protein Sorting Signals
Gene Library
Cysteine
Amino Acids
Lung

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Wainwright, B. J., Scambler, P. J., Stanier, P., Watson, E. K., Bell, G., Wicking, C., ... Pedersen, P. S. (1988). Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO Journal, 7(6), 1743-1748.

Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. / Wainwright, B. J.; Scambler, P. J.; Stanier, P.; Watson, E. K.; Bell, G.; Wicking, C.; Estivill, Xavier P.; Courtney, M.; Boue, A.; Pedersen, P. S.

In: EMBO Journal, Vol. 7, No. 6, 06.1988, p. 1743-1748.

Research output: Contribution to journalArticle

Wainwright, BJ, Scambler, PJ, Stanier, P, Watson, EK, Bell, G, Wicking, C, Estivill, XP, Courtney, M, Boue, A & Pedersen, PS 1988, 'Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.', EMBO Journal, vol. 7, no. 6, pp. 1743-1748.
Wainwright BJ, Scambler PJ, Stanier P, Watson EK, Bell G, Wicking C et al. Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO Journal. 1988 Jun;7(6):1743-1748.
Wainwright, B. J. ; Scambler, P. J. ; Stanier, P. ; Watson, E. K. ; Bell, G. ; Wicking, C. ; Estivill, Xavier P. ; Courtney, M. ; Boue, A. ; Pedersen, P. S. / Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. In: EMBO Journal. 1988 ; Vol. 7, No. 6. pp. 1743-1748.
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