Isolation and Characterization of 14 CA-Repeat Microsatellites from Human Chromosome 21

A. Bosch, V. Nunes, D. Patterson, Xavier P. Estivill

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Fourteen CA-repeat microsatellite polymorphisms from human chromosome 21 (HC21) (D21S364, D21S365, D21S366, D21S367, D21S368, D21S369, D21S406, D21S407, D21S408, D21S409, D21S410, D21S411, D21S415, and D21S1217) have been cloned from a flow-sorted phage library (LA21NS01). These microsatellite loci have been mapped using a somatic cell hybrid panel of HC21, and heterozygosities and allele frequencies have been determined. The markers spread along the length of the long arm of the HC21. Twelve of these microsatellites have heterozygosities between 0.47 and 0.90. These new CA-repeat markers will improve the genetic map of HC21.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalGenomics
Volume18
Issue number1
DOIs
Publication statusPublished - Oct 1993
Externally publishedYes

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Chromosomes, Human, Pair 21
Human Chromosomes
Microsatellite Repeats
Hybrid Cells
Gene Frequency
Bacteriophages

ASJC Scopus subject areas

  • Genetics

Cite this

Isolation and Characterization of 14 CA-Repeat Microsatellites from Human Chromosome 21. / Bosch, A.; Nunes, V.; Patterson, D.; Estivill, Xavier P.

In: Genomics, Vol. 18, No. 1, 10.1993, p. 151-155.

Research output: Contribution to journalArticle

Bosch, A. ; Nunes, V. ; Patterson, D. ; Estivill, Xavier P. / Isolation and Characterization of 14 CA-Repeat Microsatellites from Human Chromosome 21. In: Genomics. 1993 ; Vol. 18, No. 1. pp. 151-155.
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