Isolated digital gangrene complicating hepatitis A infection in a child

Samar Muwakkit, Mohammad Al-Ajam, Thurayya Arayssi, Dana Hasbini, Abdul Fattah Masri, Mohamad Mikati

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hepatitis A virus is rarely associated with extrahepatic complications. A child presented with a history suggesting Raynaud's phenomenon and severe digital gangrene, as a complication of hepatitis A infection. Coagulation study results (protein C, protein S, antithrombin III, and activated protein C resistance) were all normal except for anticardiolipin antibodies, which were present on initial presentation and resolved later. Antinuclear antibodies, rheumatoid factor, lupus anticoagulant, antineutrophilic cytoplasmic antibodies, and Venereal Disease Research Laboratory test were all negative. Cryoglobulins were not detected. C3 and C4 levels were normal. Blood urea nitrogen and creatinine levels were normal as well. The patient was treated with aspirin and diclofenac, and improved slowly with complete resolution of gangrene and symptoms after 3 months. She remains asymptomatic 4 years later. Transient antiphospholipid syndrome or isolated Raynaud's phenomenon may be added to the list of extrahepatic complications of hepatitis A.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalJournal of Clinical Rheumatology
Volume8
Issue number4
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Raynaud Disease
Gangrene
Hepatitis A
Activated Protein C Resistance
Cryoglobulins
Lupus Coagulation Inhibitor
Hepatitis A virus
Anticardiolipin Antibodies
Antiphospholipid Syndrome
Antithrombin III
Rheumatoid Factor
Diclofenac
Blood Urea Nitrogen
Antinuclear Antibodies
Protein S
Sexually Transmitted Diseases
Protein C
Infection
Aspirin
Creatinine

Keywords

  • Anticardiolipin antibodies
  • Antiphospholipid syndrome
  • Child
  • Hepatitis A
  • Raynaud's phenomenon

ASJC Scopus subject areas

  • Rheumatology

Cite this

Muwakkit, S., Al-Ajam, M., Arayssi, T., Hasbini, D., Masri, A. F., & Mikati, M. (2002). Isolated digital gangrene complicating hepatitis A infection in a child. Journal of Clinical Rheumatology, 8(4), 223-227.

Isolated digital gangrene complicating hepatitis A infection in a child. / Muwakkit, Samar; Al-Ajam, Mohammad; Arayssi, Thurayya; Hasbini, Dana; Masri, Abdul Fattah; Mikati, Mohamad.

In: Journal of Clinical Rheumatology, Vol. 8, No. 4, 2002, p. 223-227.

Research output: Contribution to journalArticle

Muwakkit, S, Al-Ajam, M, Arayssi, T, Hasbini, D, Masri, AF & Mikati, M 2002, 'Isolated digital gangrene complicating hepatitis A infection in a child', Journal of Clinical Rheumatology, vol. 8, no. 4, pp. 223-227.
Muwakkit S, Al-Ajam M, Arayssi T, Hasbini D, Masri AF, Mikati M. Isolated digital gangrene complicating hepatitis A infection in a child. Journal of Clinical Rheumatology. 2002;8(4):223-227.
Muwakkit, Samar ; Al-Ajam, Mohammad ; Arayssi, Thurayya ; Hasbini, Dana ; Masri, Abdul Fattah ; Mikati, Mohamad. / Isolated digital gangrene complicating hepatitis A infection in a child. In: Journal of Clinical Rheumatology. 2002 ; Vol. 8, No. 4. pp. 223-227.
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