Is there a difference in progression of renal disease between South Asian and white European diabetic adults with moderately reduced kidney function?

Maria Pallayova, Hugh Rayner, Shahrad Taheri, Indranil Dasgupta

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Abstract

Aims: We examined potential ethnicity-related differences in progression of chronic kidney disease (CKD) between South Asian and white European diabetic adults with CKD stage 3 over a 5-year period. Methods: We analysed data collected from diabetic adults of white European and South Asian ethnicity who had attended diabetes and diabetes-renal outpatient clinics with baseline estimated glomerular filtration rate (eGFR) values ≥30 and <60 ml/min/1.73 m2 over 5 years (2005-2010); 891 (76%) were white Europeans, 282 (24%) were South Asians. Results: Despite similar baseline eGFR (P = 0.103), South Asians were younger [median (interquartile range) 68 (63-73) vs. 70 (64-77) years; P < 0.001] and had worse baseline glycated haemoglobin than white Europeans [8.0 (7.0-9.1) vs. 7.6 (6.8-8.7)%; P = 0.004]. The 5-year follow-up eGFR and the decline in eGFR did not differ between the two groups. Thirty-five (12.4%) South Asians and 82 (9.2%) white Europeans progressed to stages 4-5 CKD (P = 0.112). There was a trend towards higher follow-up glycated haemoglobin levels in South Asians (P = 0.064). Conclusions: Despite worse glycaemic control, South Asian diabetic adults with CKD stage 3 did not show any difference in 5-year decline in eGFR compared with white Europeans. These data do not support ethnic differences in progression of CKD between the South Asian and white European patient populations.

Original languageEnglish
Pages (from-to)761-765
Number of pages5
JournalJournal of Diabetes and its Complications
Volume29
Issue number6
DOIs
Publication statusPublished - 2015

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Glomerular Filtration Rate
Chronic Renal Insufficiency
Disease Progression
Kidney
Glycosylated Hemoglobin A
Ambulatory Care Facilities
Population

Keywords

  • Chronic kidney disease
  • Diabetes mellitus
  • Estimated glomerular filtration rate
  • Ethnicity
  • Glycated haemoglobin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{7ac6b1f9d2804d04b013ea5b1b40c7b3,
title = "Is there a difference in progression of renal disease between South Asian and white European diabetic adults with moderately reduced kidney function?",
abstract = "Aims: We examined potential ethnicity-related differences in progression of chronic kidney disease (CKD) between South Asian and white European diabetic adults with CKD stage 3 over a 5-year period. Methods: We analysed data collected from diabetic adults of white European and South Asian ethnicity who had attended diabetes and diabetes-renal outpatient clinics with baseline estimated glomerular filtration rate (eGFR) values ≥30 and <60 ml/min/1.73 m2 over 5 years (2005-2010); 891 (76{\%}) were white Europeans, 282 (24{\%}) were South Asians. Results: Despite similar baseline eGFR (P = 0.103), South Asians were younger [median (interquartile range) 68 (63-73) vs. 70 (64-77) years; P < 0.001] and had worse baseline glycated haemoglobin than white Europeans [8.0 (7.0-9.1) vs. 7.6 (6.8-8.7){\%}; P = 0.004]. The 5-year follow-up eGFR and the decline in eGFR did not differ between the two groups. Thirty-five (12.4{\%}) South Asians and 82 (9.2{\%}) white Europeans progressed to stages 4-5 CKD (P = 0.112). There was a trend towards higher follow-up glycated haemoglobin levels in South Asians (P = 0.064). Conclusions: Despite worse glycaemic control, South Asian diabetic adults with CKD stage 3 did not show any difference in 5-year decline in eGFR compared with white Europeans. These data do not support ethnic differences in progression of CKD between the South Asian and white European patient populations.",
keywords = "Chronic kidney disease, Diabetes mellitus, Estimated glomerular filtration rate, Ethnicity, Glycated haemoglobin",
author = "Maria Pallayova and Hugh Rayner and Shahrad Taheri and Indranil Dasgupta",
year = "2015",
doi = "10.1016/j.jdiacomp.2015.05.012",
language = "English",
volume = "29",
pages = "761--765",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",
number = "6",

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TY - JOUR

T1 - Is there a difference in progression of renal disease between South Asian and white European diabetic adults with moderately reduced kidney function?

AU - Pallayova, Maria

AU - Rayner, Hugh

AU - Taheri, Shahrad

AU - Dasgupta, Indranil

PY - 2015

Y1 - 2015

N2 - Aims: We examined potential ethnicity-related differences in progression of chronic kidney disease (CKD) between South Asian and white European diabetic adults with CKD stage 3 over a 5-year period. Methods: We analysed data collected from diabetic adults of white European and South Asian ethnicity who had attended diabetes and diabetes-renal outpatient clinics with baseline estimated glomerular filtration rate (eGFR) values ≥30 and <60 ml/min/1.73 m2 over 5 years (2005-2010); 891 (76%) were white Europeans, 282 (24%) were South Asians. Results: Despite similar baseline eGFR (P = 0.103), South Asians were younger [median (interquartile range) 68 (63-73) vs. 70 (64-77) years; P < 0.001] and had worse baseline glycated haemoglobin than white Europeans [8.0 (7.0-9.1) vs. 7.6 (6.8-8.7)%; P = 0.004]. The 5-year follow-up eGFR and the decline in eGFR did not differ between the two groups. Thirty-five (12.4%) South Asians and 82 (9.2%) white Europeans progressed to stages 4-5 CKD (P = 0.112). There was a trend towards higher follow-up glycated haemoglobin levels in South Asians (P = 0.064). Conclusions: Despite worse glycaemic control, South Asian diabetic adults with CKD stage 3 did not show any difference in 5-year decline in eGFR compared with white Europeans. These data do not support ethnic differences in progression of CKD between the South Asian and white European patient populations.

AB - Aims: We examined potential ethnicity-related differences in progression of chronic kidney disease (CKD) between South Asian and white European diabetic adults with CKD stage 3 over a 5-year period. Methods: We analysed data collected from diabetic adults of white European and South Asian ethnicity who had attended diabetes and diabetes-renal outpatient clinics with baseline estimated glomerular filtration rate (eGFR) values ≥30 and <60 ml/min/1.73 m2 over 5 years (2005-2010); 891 (76%) were white Europeans, 282 (24%) were South Asians. Results: Despite similar baseline eGFR (P = 0.103), South Asians were younger [median (interquartile range) 68 (63-73) vs. 70 (64-77) years; P < 0.001] and had worse baseline glycated haemoglobin than white Europeans [8.0 (7.0-9.1) vs. 7.6 (6.8-8.7)%; P = 0.004]. The 5-year follow-up eGFR and the decline in eGFR did not differ between the two groups. Thirty-five (12.4%) South Asians and 82 (9.2%) white Europeans progressed to stages 4-5 CKD (P = 0.112). There was a trend towards higher follow-up glycated haemoglobin levels in South Asians (P = 0.064). Conclusions: Despite worse glycaemic control, South Asian diabetic adults with CKD stage 3 did not show any difference in 5-year decline in eGFR compared with white Europeans. These data do not support ethnic differences in progression of CKD between the South Asian and white European patient populations.

KW - Chronic kidney disease

KW - Diabetes mellitus

KW - Estimated glomerular filtration rate

KW - Ethnicity

KW - Glycated haemoglobin

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U2 - 10.1016/j.jdiacomp.2015.05.012

DO - 10.1016/j.jdiacomp.2015.05.012

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VL - 29

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JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 6

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