Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production

Yago Pico de Coaña, Isabel Poschke, Giusy Gentilcore, Yumeng Mao, Maria Nyström, Johan Hansson, Giuseppe V. Masucci, Rolf Kiessling

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64 Citations (Scopus)

Abstract

Blocking the immune checkpoint molecule CTL antigen-4 (CTLA-4) with ipilimumab has proven to induce long-lasting clinical responses in patients with metastatic melanoma. To study the early response that takes place after CTLA-4 blockade, peripheral blood immune monitoring was conducted in five patients undergoing ipilimumab treatment at baseline, three and nine weeks after administration of the first dose. Along with T-cell population analysis, this work was primarily focused on an in-depth study of the myeloid-derived suppressor cell (MDSC) populations. Ipilimumab treatment resulted in lower frequencies of regulatory T cells along with reduced expression levels of PD-1 at the nine-week time point. Three weeks after the initial ipilimumab dose, the frequency of granulocytic MDSCs was significantly reduced and was followed by a reduction in the frequency of arginase1-producing CD3(-) cells, indicating an indirect in trans effect that should be taken into account for future evaluations of ipilimumab mechanisms of action.

Original languageEnglish
Pages (from-to)158-162
Number of pages5
JournalCancer Immunology Research
Volume1
Issue number3
DOIs
Publication statusPublished - 1 Sep 2013

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ASJC Scopus subject areas

  • Immunology
  • Cancer Research

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