Ion transporters, channelopathies, and glucose disorders

Huseyin Demirbilek, Sonya Galcheva, Dogus Vuralli, Sara Al-Khawaga, Khalid Hussain

Research output: Contribution to journalReview article

Abstract

Ion channels and transporters play essential roles in excitable cells including cardiac, skeletal and smooth muscle cells, neurons, and endocrine cells. In pancreatic beta-cells, for example, potassium KATP channels link the metabolic signals generated inside the cell to changes in the beta-cell membrane potential, and ultimately regulate insulin secretion. Mutations in the genes encoding some ion transporter and channel proteins lead to disorders of glucose homeostasis (hyperinsulinaemic hypoglycaemia and different forms of diabetes mellitus). Pancreatic KATP, Non-KATP, and some calcium channelopathies and MCT1 transporter defects can lead to various forms of hyperinsulinaemic hypoglycaemia (HH). Mutations in the genes encoding the pancreatic KATP channels can also lead to different types of diabetes (including neonatal diabetes mellitus (NDM) and Maturity Onset Diabetes of the Young, MODY), and defects in the solute carrier family 2 member 2 (SLC2A2) leads to diabetes mellitus as part of the Fanconi–Bickel syndrome. Variants or polymorphisms in some ion channel genes and transporters have been reported in association with type 2 diabetes mellitus.

Original languageEnglish
Article number2590
JournalInternational journal of molecular sciences
Volume20
Issue number10
DOIs
Publication statusPublished - 2 May 2019

Fingerprint

Channelopathies
diabetes mellitus
transporter
Facilitative Glucose Transport Proteins
Medical problems
Ion Channels
glucose
Glucose
hypoglycemia
KATP Channels
Diabetes Mellitus
disorders
genes
Ions
Hypoglycemia
Type 2 Diabetes Mellitus
mutations
Genes
Mutation
ions

Keywords

  • Beta cell
  • Hyperinsulinaemic hypoglycaemia
  • K channel
  • Membrane transporters
  • Neonatal diabetes
  • Voltage-gated calcium channels

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Ion transporters, channelopathies, and glucose disorders. / Demirbilek, Huseyin; Galcheva, Sonya; Vuralli, Dogus; Al-Khawaga, Sara; Hussain, Khalid.

In: International journal of molecular sciences, Vol. 20, No. 10, 2590, 02.05.2019.

Research output: Contribution to journalReview article

Demirbilek, Huseyin ; Galcheva, Sonya ; Vuralli, Dogus ; Al-Khawaga, Sara ; Hussain, Khalid. / Ion transporters, channelopathies, and glucose disorders. In: International journal of molecular sciences. 2019 ; Vol. 20, No. 10.
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