Ion channel function during oocyte maturation and fertilization

Ingrid Carvacho, Matthias Piesche, Thorsten J. Maier, Khaled Machaca

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The proper maturation of both male and female gametes is essential for supporting fertilization and the early embryonic divisions. In the ovary, immature fully-grown oocytes that are arrested in prophase I of meiosis I are not able to support fertilization. Acquiring fertilization competence requires resumption of meiosis which encompasses the remodeling of multiple signaling pathways and the reorganization of cellular organelles. Collectively, this differentiation endows the egg with the ability to activate at fertilization and to promote the egg-to-embryo transition. Oocyte maturation is associated with changes in the electrical properties of the plasma membrane and alterations in the function and distribution of ion channels. Therefore, variations on the pattern of expression, distribution, and function of ion channels and transporters during oocyte maturation are fundamental to reproductive success. Ion channels and transporters are important in regulating membrane potential, but also in the case of calcium (Ca2+), they play a critical role in modulating intracellular signaling pathways. In the context of fertilization, Ca2+ has been shown to be the universal activator of development at fertilization, playing a central role in early events associated with egg activation and the egg-to-embryo transition. These early events include the block of polyspermy, the completion of meiosis and the transition to the embryonic mitotic divisions. In this review, we discuss the role of ion channels during oocyte maturation, fertilization and early embryonic development. We will describe how ion channel studies in Xenopus oocytes, an extensively studied model of oocyte maturation, translate into a greater understanding of the role of ion channels in mammalian oocyte physiology.

Original languageEnglish
Article number63
JournalFrontiers in Cell and Developmental Biology
Volume6
Issue numberJUN
DOIs
Publication statusPublished - 26 Jun 2018

Fingerprint

Ion Channels
Fertilization
Oocytes
Ovum
Meiosis
Embryonic Structures
Meiotic Prophase I
Aptitude
Xenopus
Germ Cells
Organelles
Membrane Potentials
Mental Competency
Embryonic Development
Ovary
Cell Membrane
Calcium

Keywords

  • Ca signaling
  • Fertilization
  • Ion currents
  • Membrane potential
  • Oocyte maturation
  • Patch-clamp

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Ion channel function during oocyte maturation and fertilization. / Carvacho, Ingrid; Piesche, Matthias; Maier, Thorsten J.; Machaca, Khaled.

In: Frontiers in Cell and Developmental Biology, Vol. 6, No. JUN, 63, 26.06.2018.

Research output: Contribution to journalReview article

Carvacho, Ingrid ; Piesche, Matthias ; Maier, Thorsten J. ; Machaca, Khaled. / Ion channel function during oocyte maturation and fertilization. In: Frontiers in Cell and Developmental Biology. 2018 ; Vol. 6, No. JUN.
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