Involvement of lipoproteins, free radicals, and calcium in cardiovascular disease processes

Hamid Massaeli, G. N. Pierce

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Low density lipoproteins have the capacity to alter cell calcium concentrations of a wide variety of cell types. The precise mechanism of physical interaction of the LDL or its products with the cell is not defined yet. There is more agreement about the calcium transport pathway affected. Most studies show an ability of LDL to alter transsarcolemmal calcium flux, probably through the slow calcium channel. However, internal stores of calcium like the sarcoplasmic reticulum also appear to be altered. These effects of LDL on cellular calcium homeostasis have potential importance in both physiological and disease settings. Oxidised LDL has even more potential significance than the native LDL in disease conditions. Free radical mediated oxidation of LDL during atherosclerotic and ischaemic conditions creates a molecule with even greater potency for altering cell calcium and ultimately cell function and viability. The interaction of this trio of compounds - LDL, free radicals, and cellular calcium - may be critical for the mechanism of pathogenesis in specific cardiovascular diseases. It will be important in the future to identify new therapeutic strategies to prevent their interaction.

Original languageEnglish
Pages (from-to)597-603
Number of pages7
JournalCardiovascular Research
Volume29
Issue number5
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Fingerprint

Lipoproteins
Free Radicals
Cardiovascular Diseases
Calcium
Sarcoplasmic Reticulum
Calcium Channels
LDL Lipoproteins
oxidized low density lipoprotein
Cell Survival
Homeostasis

Keywords

  • Atherosclerosis
  • Calcium
  • Ischaemia
  • Low density lipoprotein
  • Oxidised low density lipoprotein
  • Oxygen derived free radicals

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Involvement of lipoproteins, free radicals, and calcium in cardiovascular disease processes. / Massaeli, Hamid; Pierce, G. N.

In: Cardiovascular Research, Vol. 29, No. 5, 01.01.1995, p. 597-603.

Research output: Contribution to journalReview article

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