Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia

Nayef E. Saadé, Stella Major, Suhayl J. Jabbur, Samir F. Atweh, Salim A. Kanaan, Bared Safieh-Garabedian

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin- induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1β. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalJournal of Neuroimmunology
Volume91
Issue number1-2
DOIs
Publication statusPublished - 2 Nov 1998
Externally publishedYes

Fingerprint

Circulating Thymic Factor
Capsaicin
Hyperalgesia
Vagotomy
Nerve Growth Factor
Interleukin-1
Injections
Therapeutics

Keywords

  • Capsaicin
  • Hyperalgesia
  • NGF, interleukin
  • Thymulin
  • Vagus

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Saadé, N. E., Major, S., Jabbur, S. J., Atweh, S. F., Kanaan, S. A., & Safieh-Garabedian, B. (1998). Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia. Journal of Neuroimmunology, 91(1-2), 171-179. https://doi.org/10.1016/S0165-5728(98)00176-3

Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia. / Saadé, Nayef E.; Major, Stella; Jabbur, Suhayl J.; Atweh, Samir F.; Kanaan, Salim A.; Safieh-Garabedian, Bared.

In: Journal of Neuroimmunology, Vol. 91, No. 1-2, 02.11.1998, p. 171-179.

Research output: Contribution to journalArticle

Saadé, NE, Major, S, Jabbur, SJ, Atweh, SF, Kanaan, SA & Safieh-Garabedian, B 1998, 'Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia', Journal of Neuroimmunology, vol. 91, no. 1-2, pp. 171-179. https://doi.org/10.1016/S0165-5728(98)00176-3
Saadé, Nayef E. ; Major, Stella ; Jabbur, Suhayl J. ; Atweh, Samir F. ; Kanaan, Salim A. ; Safieh-Garabedian, Bared. / Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia. In: Journal of Neuroimmunology. 1998 ; Vol. 91, No. 1-2. pp. 171-179.
@article{9e68c984e7ab470ea86b7e7a52ce3c7f,
title = "Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia",
abstract = "Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin- induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1β. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.",
keywords = "Capsaicin, Hyperalgesia, NGF, interleukin, Thymulin, Vagus",
author = "Saad{\'e}, {Nayef E.} and Stella Major and Jabbur, {Suhayl J.} and Atweh, {Samir F.} and Kanaan, {Salim A.} and Bared Safieh-Garabedian",
year = "1998",
month = "11",
day = "2",
doi = "10.1016/S0165-5728(98)00176-3",
language = "English",
volume = "91",
pages = "171--179",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia

AU - Saadé, Nayef E.

AU - Major, Stella

AU - Jabbur, Suhayl J.

AU - Atweh, Samir F.

AU - Kanaan, Salim A.

AU - Safieh-Garabedian, Bared

PY - 1998/11/2

Y1 - 1998/11/2

N2 - Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin- induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1β. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.

AB - Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin- induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1β. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.

KW - Capsaicin

KW - Hyperalgesia

KW - NGF, interleukin

KW - Thymulin

KW - Vagus

UR - http://www.scopus.com/inward/record.url?scp=0032476718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032476718&partnerID=8YFLogxK

U2 - 10.1016/S0165-5728(98)00176-3

DO - 10.1016/S0165-5728(98)00176-3

M3 - Article

VL - 91

SP - 171

EP - 179

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -