Investigating physiological glucose excursions before, during, and after Ramadan in adults without diabetes mellitus

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Abstract

Aim The study aimed to investigate physiological effects of Ramadan fasting on continuously monitored glucose levels in relation to Ramadan in young non-diabetic adults. Methods Continuous glucose monitoring was employed to measure interstitial glucose for several days 1–2 weeks before Ramadan, in the middle of Ramadan, and 4–6 weeks after Ramadan to assess glucose exposure and glucose variability. Results A total of 34,182 accurate glucose sensor readings and 438 capillary blood glucose values [mean absolute difference median (interquartile range) 8.5 (6.9–11.1)%] were obtained from 18 non-diabetic adults [13 females; aged 24 (21–27) years; baseline body mass index 23.9 (20.6–28.9) kg/m2]. The continuous glucose monitoring profiles showed an increase in the hyperglycemic (above 140 mg/dL) area under the curve after Ramadan compared to both before (P = 0.004) and during Ramadan (P = 0.003), along with an increased glucose variability after Ramadan (P = 0.014). Both the area under the interstitial glucose concentration curve for the entire day and the average glucose were positively associated with body mass index during (P = 0.004 and P = 0.005, respectively) and after Ramadan (P = 0.013 and P = 0.01, respectively). Atypical continuous glucose patterns were recognized in 11% of subjects, distinguished by a prolonged increased glucose exposure, particularly in response to a meal. Conclusion The time-point 4–6 weeks after Ramadan was distinguished by greater glucose exposure and wider glucose variability that may reflect ongoing changes in insulin sensitivity in response to altering lifestyle patterns in non-diabetic young adults across the spectrum of body weight.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalPhysiology and Behavior
Volume179
DOIs
Publication statusPublished - 1 Oct 2017

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Diabetes Mellitus
Glucose
Body Mass Index
Area Under Curve
Meals
Insulin Resistance
Blood Glucose
Life Style
Reading
Young Adult
Fasting
Body Weight

Keywords

  • Continuous glucose monitoring
  • Fasting
  • Glucose exposure
  • Glucose variability
  • Ramadan

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

@article{df07618a6fc047d08aef70e75c02f0b1,
title = "Investigating physiological glucose excursions before, during, and after Ramadan in adults without diabetes mellitus",
abstract = "Aim The study aimed to investigate physiological effects of Ramadan fasting on continuously monitored glucose levels in relation to Ramadan in young non-diabetic adults. Methods Continuous glucose monitoring was employed to measure interstitial glucose for several days 1–2 weeks before Ramadan, in the middle of Ramadan, and 4–6 weeks after Ramadan to assess glucose exposure and glucose variability. Results A total of 34,182 accurate glucose sensor readings and 438 capillary blood glucose values [mean absolute difference median (interquartile range) 8.5 (6.9–11.1){\%}] were obtained from 18 non-diabetic adults [13 females; aged 24 (21–27) years; baseline body mass index 23.9 (20.6–28.9) kg/m2]. The continuous glucose monitoring profiles showed an increase in the hyperglycemic (above 140 mg/dL) area under the curve after Ramadan compared to both before (P = 0.004) and during Ramadan (P = 0.003), along with an increased glucose variability after Ramadan (P = 0.014). Both the area under the interstitial glucose concentration curve for the entire day and the average glucose were positively associated with body mass index during (P = 0.004 and P = 0.005, respectively) and after Ramadan (P = 0.013 and P = 0.01, respectively). Atypical continuous glucose patterns were recognized in 11{\%} of subjects, distinguished by a prolonged increased glucose exposure, particularly in response to a meal. Conclusion The time-point 4–6 weeks after Ramadan was distinguished by greater glucose exposure and wider glucose variability that may reflect ongoing changes in insulin sensitivity in response to altering lifestyle patterns in non-diabetic young adults across the spectrum of body weight.",
keywords = "Continuous glucose monitoring, Fasting, Glucose exposure, Glucose variability, Ramadan",
author = "Maria Pallayova and Hadeel Zaghloul and Teresa Arora and Sopna Choudhury and Omar Omar and Odette Chagoury and Shahrad Taheri",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.physbeh.2017.05.032",
language = "English",
volume = "179",
pages = "110--115",
journal = "Physiology and Behavior",
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TY - JOUR

T1 - Investigating physiological glucose excursions before, during, and after Ramadan in adults without diabetes mellitus

AU - Pallayova, Maria

AU - Zaghloul, Hadeel

AU - Arora, Teresa

AU - Choudhury, Sopna

AU - Omar, Omar

AU - Chagoury, Odette

AU - Taheri, Shahrad

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Aim The study aimed to investigate physiological effects of Ramadan fasting on continuously monitored glucose levels in relation to Ramadan in young non-diabetic adults. Methods Continuous glucose monitoring was employed to measure interstitial glucose for several days 1–2 weeks before Ramadan, in the middle of Ramadan, and 4–6 weeks after Ramadan to assess glucose exposure and glucose variability. Results A total of 34,182 accurate glucose sensor readings and 438 capillary blood glucose values [mean absolute difference median (interquartile range) 8.5 (6.9–11.1)%] were obtained from 18 non-diabetic adults [13 females; aged 24 (21–27) years; baseline body mass index 23.9 (20.6–28.9) kg/m2]. The continuous glucose monitoring profiles showed an increase in the hyperglycemic (above 140 mg/dL) area under the curve after Ramadan compared to both before (P = 0.004) and during Ramadan (P = 0.003), along with an increased glucose variability after Ramadan (P = 0.014). Both the area under the interstitial glucose concentration curve for the entire day and the average glucose were positively associated with body mass index during (P = 0.004 and P = 0.005, respectively) and after Ramadan (P = 0.013 and P = 0.01, respectively). Atypical continuous glucose patterns were recognized in 11% of subjects, distinguished by a prolonged increased glucose exposure, particularly in response to a meal. Conclusion The time-point 4–6 weeks after Ramadan was distinguished by greater glucose exposure and wider glucose variability that may reflect ongoing changes in insulin sensitivity in response to altering lifestyle patterns in non-diabetic young adults across the spectrum of body weight.

AB - Aim The study aimed to investigate physiological effects of Ramadan fasting on continuously monitored glucose levels in relation to Ramadan in young non-diabetic adults. Methods Continuous glucose monitoring was employed to measure interstitial glucose for several days 1–2 weeks before Ramadan, in the middle of Ramadan, and 4–6 weeks after Ramadan to assess glucose exposure and glucose variability. Results A total of 34,182 accurate glucose sensor readings and 438 capillary blood glucose values [mean absolute difference median (interquartile range) 8.5 (6.9–11.1)%] were obtained from 18 non-diabetic adults [13 females; aged 24 (21–27) years; baseline body mass index 23.9 (20.6–28.9) kg/m2]. The continuous glucose monitoring profiles showed an increase in the hyperglycemic (above 140 mg/dL) area under the curve after Ramadan compared to both before (P = 0.004) and during Ramadan (P = 0.003), along with an increased glucose variability after Ramadan (P = 0.014). Both the area under the interstitial glucose concentration curve for the entire day and the average glucose were positively associated with body mass index during (P = 0.004 and P = 0.005, respectively) and after Ramadan (P = 0.013 and P = 0.01, respectively). Atypical continuous glucose patterns were recognized in 11% of subjects, distinguished by a prolonged increased glucose exposure, particularly in response to a meal. Conclusion The time-point 4–6 weeks after Ramadan was distinguished by greater glucose exposure and wider glucose variability that may reflect ongoing changes in insulin sensitivity in response to altering lifestyle patterns in non-diabetic young adults across the spectrum of body weight.

KW - Continuous glucose monitoring

KW - Fasting

KW - Glucose exposure

KW - Glucose variability

KW - Ramadan

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U2 - 10.1016/j.physbeh.2017.05.032

DO - 10.1016/j.physbeh.2017.05.032

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VL - 179

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JF - Physiology and Behavior

SN - 0031-9384

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