Investigating effects of copy number alterations on targeted therapy response using a conditioning-based model

Fang Han Hsu, Erchin Serpedin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Emerging targeted therapies have shown benefits such as less toxicity and higher effectiveness in specific types of cancer treatment; however, the accessibility of these advantages may rely on sufficient understanding of mechanisms causing resistance and correct identification of suitable patients, which remain highly immature. Based on the fact that copy number alterations (CNAs) may affect expression levels and regulatory activities, CNAs are assumed to be capable of interfering with signal transduction and influence targeted drug effectiveness. Considering the mechanism of action (MOA) of trastuzumab in the ERBB2-ERK signaling pathway, a conditioning-based model in which copy number alterations (CNAs) serve as latent parents modifying signal transduction is applied. Using mathematical induction, the upstream and downstream CNAs are found to have equal influence on drug effectiveness. Two scoring functions, M-score and R-value, are further proposed to provide qualitative and quantitative information regarding the unfavorableness of a CNA on drug utility and thereby shed light on personalized therapy.

Original languageEnglish
Title of host publication2014 Middle East Conference on Biomedical Engineering, MECBME 2014
PublisherIEEE Computer Society
Pages163-166
Number of pages4
ISBN (Print)9781479947997
DOIs
Publication statusPublished - 2014
Externally publishedYes
Event2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014 - Doha, Qatar
Duration: 17 Feb 201420 Feb 2014

Other

Other2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014
CountryQatar
CityDoha
Period17/2/1420/2/14

Fingerprint

Signal transduction
Oncology
Toxicity

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Hsu, F. H., & Serpedin, E. (2014). Investigating effects of copy number alterations on targeted therapy response using a conditioning-based model. In 2014 Middle East Conference on Biomedical Engineering, MECBME 2014 (pp. 163-166). [6783231] IEEE Computer Society. https://doi.org/10.1109/MECBME.2014.6783231

Investigating effects of copy number alterations on targeted therapy response using a conditioning-based model. / Hsu, Fang Han; Serpedin, Erchin.

2014 Middle East Conference on Biomedical Engineering, MECBME 2014. IEEE Computer Society, 2014. p. 163-166 6783231.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hsu, FH & Serpedin, E 2014, Investigating effects of copy number alterations on targeted therapy response using a conditioning-based model. in 2014 Middle East Conference on Biomedical Engineering, MECBME 2014., 6783231, IEEE Computer Society, pp. 163-166, 2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014, Doha, Qatar, 17/2/14. https://doi.org/10.1109/MECBME.2014.6783231
Hsu FH, Serpedin E. Investigating effects of copy number alterations on targeted therapy response using a conditioning-based model. In 2014 Middle East Conference on Biomedical Engineering, MECBME 2014. IEEE Computer Society. 2014. p. 163-166. 6783231 https://doi.org/10.1109/MECBME.2014.6783231
Hsu, Fang Han ; Serpedin, Erchin. / Investigating effects of copy number alterations on targeted therapy response using a conditioning-based model. 2014 Middle East Conference on Biomedical Engineering, MECBME 2014. IEEE Computer Society, 2014. pp. 163-166
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