Intraoperative parathyroid hormone monitoring to determine long-term success of total parathyroidectomy for secondary hyperparathyroidism

James W. Moor, Steven Roberts, Stephen Atkin, R. James A England

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background Use of intraoperative parathyroid hormone (ioPTH) monitoring during total parathyroidectomy for secondary hyperparathyroidism is common, although its ability to predict long-term normoparathyroid state is not known. Methods Prospective evaluation of 57 consecutive patients undergoing total parathyroidectomy for renal hyperparathyroidism with ioPTH monitoring and follow-up PTH assays were used to categorize the patients into 3 groups: success, adequate biochemical control, and failure. Results There was no statistically significant difference in percentage reduction of ioPTH between the 3 groups (p =.07), although there was a moderate negative correlation between percentage reduction of ioPTH and percentage reduction of PTH at follow-up (R = 0.57). Conclusions When used under current guidelines, ioPTH monitoring is of no use in predicting long-term cure for these patients because it does not predict success. Patients that undergo total parathyroidectomy are required to have long-term calcium and PTH assay follow-up because normoparathyroidism cannot be assumed. Using the regression equation calculated, success may be predicted for future patients.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalHead and Neck
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

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Keywords

  • follow-up studies
  • intraoperative monitoring
  • parathyroid hormone
  • parathyroidectomy
  • secondary hyperparathyroidism

ASJC Scopus subject areas

  • Otorhinolaryngology

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