Intraluminal fibrosis in interstitial lung disorders

F. Basset, V. J. Ferrans, P. Soler, T. Takemura, Y. Fukuda, Ronald Crystal

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

The histopathologic and ultrastructural features of intraluminal organizing and fibrotic changes were studied in open lung biopsies and autopsy specimens from 373 patients with interstitial lung disorders, including hypersensitivity pneumonitis (n = 44), idiopathic pulmonary fibrosis (n = 92), collagen-vascular diseases (n = 20), chronic eosinophilic pneumonia (n = 10), pulmonary histiocytosis X (n = 90), pulmonary sarcoidosis (n = 62), pneumoconioses (n = 25), Legionnaire's disease (n = 5), drug- and toxin-induced pneumonitis (n = 4), radiation-induced pneumonitis (n = 2), lymphangioleiomyomatosis (n = 11), and chronic organizing pneumonia of unknown cause (n = 8). Three patterns of intraluminal organization and fibrosis were recognized: 1) intraluminal buds, which partially filled the alveoli, alveolar ducts and/or distal bronchioles; 2) obliterative changes, in which loose connective tissue masses obliterated the lumens of alveoli, alveolar ducts or distal bronchioles, and 3) mural incorporation of previously intraluminal connective tissue masses, which fused with alveolar, alveolar ductal, or bronchiolar structures and frequently became reepithelialized. All three patterns had common morphologic features, suggesting that, regardless of their severity, they resulted from a common pathogenetic mechanism, ie, the migration of activated connective tissue cells, through defects in the epithelial lining and its basement membrane, from the interstitial into the intraluminal compartment. Intraluminal buds were observed most frequently in hypersensitivity pneumonitis, chronic eosinophilic pneumonia, and organizing pneumonia of unknown cause. Mural incorporation and, to a lesser extent, obliterative changes were observed in most interstitial disorders and were very prominent in idiopathic pulmonary fibrosis. Mural incorporation and obliterative changes play an important role in pulmonary remodeling, especially when several adjacent alveoli and/or other air spaces are involved. Under these circumstances, intraluminal organization can mediate the fusion of adjacent alveolar structures by intraluminal connective tissue.

Original languageEnglish
Pages (from-to)443-461
Number of pages19
JournalAmerican Journal of Pathology
Volume122
Issue number3
Publication statusPublished - 19 Nov 1986
Externally publishedYes

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Connective Tissue
Extrinsic Allergic Alveolitis
Bronchioles
Pneumonia
Idiopathic Pulmonary Fibrosis
Fibrosis
Lung
Lymphangioleiomyomatosis
Radiation Pneumonitis
Pulmonary Sarcoidosis
Connective Tissue Cells
Legionnaires' Disease
Pneumoconiosis
Collagen Diseases
Langerhans Cell Histiocytosis
Vascular Diseases
Basement Membrane
Autopsy
Air
Organizations

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Basset, F., Ferrans, V. J., Soler, P., Takemura, T., Fukuda, Y., & Crystal, R. (1986). Intraluminal fibrosis in interstitial lung disorders. American Journal of Pathology, 122(3), 443-461.

Intraluminal fibrosis in interstitial lung disorders. / Basset, F.; Ferrans, V. J.; Soler, P.; Takemura, T.; Fukuda, Y.; Crystal, Ronald.

In: American Journal of Pathology, Vol. 122, No. 3, 19.11.1986, p. 443-461.

Research output: Contribution to journalArticle

Basset, F, Ferrans, VJ, Soler, P, Takemura, T, Fukuda, Y & Crystal, R 1986, 'Intraluminal fibrosis in interstitial lung disorders', American Journal of Pathology, vol. 122, no. 3, pp. 443-461.
Basset F, Ferrans VJ, Soler P, Takemura T, Fukuda Y, Crystal R. Intraluminal fibrosis in interstitial lung disorders. American Journal of Pathology. 1986 Nov 19;122(3):443-461.
Basset, F. ; Ferrans, V. J. ; Soler, P. ; Takemura, T. ; Fukuda, Y. ; Crystal, Ronald. / Intraluminal fibrosis in interstitial lung disorders. In: American Journal of Pathology. 1986 ; Vol. 122, No. 3. pp. 443-461.
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