Intracellular degradation of newly synthesized collagen

S. I. Rennard, L. E. Stier, R. G. Crystal

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The intracellular degradation of newly synthesized collagen is a cellular pathway that accounts for the destruction of 10-60% of collagen synthesized by a variety of cell types prior to secretion. This pathway can serve in a regulatory role to limit the secretion of defective molecules, and, in response to some extracellular mediators, regulates the amount and type of collagens secreted. In addition, this pathway may contribute to the pathogenesis of a variety of conditions affecting the extracellular matrix including fibrosis, diabetes mellitus, and scurvy.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalJournal of Investigative Dermatology
Issue numberSuppl. 1
Publication statusPublished - 1 Jan 1982


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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