Intestinal transplantation in children under FK 506 immunosuppression

Andreas G. Tzakis, Satoru Todo, Jorge Reyes, Bakr Nour, Kareem Abu-Elmagd, Rick Selby, Adrian Casavilla, Samuel Kocoshis, Anthony J. Demetris, Eduardo Yunis, David H. Van Thiel, Thomas E. Starzl

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Intestinal transplantation, solitary (n = 3) or in combination with the liver (n = 7), was performed in 10 pediatric patients with intestinal failure. The liver was only replaced if there was liver failure and portal hypertension. Immunosuppression was based on FK 506. Two patients died, one of graft-versus-host disease and one of lymphoproliferative disease. One patient was still in the intensive care unit 1 month posttransplantation due to perioperative complications. The function of the intestinal grafts in the remaining patients is normal. All nutrition and medications including immunosuppression are being administered enterally. This series indicates that small bowel transplantation, alone or in combination with the liver, is feasible in pediatric patients.

Original languageEnglish
Pages (from-to)1040-1043
Number of pages4
JournalJournal of Pediatric Surgery
Volume28
Issue number8
DOIs
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Tacrolimus
Immunosuppression
Transplantation
Liver
Pediatrics
Liver Failure
Portal Hypertension
Graft vs Host Disease
Intensive Care Units
Transplants

Keywords

  • FK 506 immunosuppression
  • Intestinal transplantation
  • liver transplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Tzakis, A. G., Todo, S., Reyes, J., Nour, B., Abu-Elmagd, K., Selby, R., ... Starzl, T. E. (1993). Intestinal transplantation in children under FK 506 immunosuppression. Journal of Pediatric Surgery, 28(8), 1040-1043. https://doi.org/10.1016/0022-3468(93)90514-L

Intestinal transplantation in children under FK 506 immunosuppression. / Tzakis, Andreas G.; Todo, Satoru; Reyes, Jorge; Nour, Bakr; Abu-Elmagd, Kareem; Selby, Rick; Casavilla, Adrian; Kocoshis, Samuel; Demetris, Anthony J.; Yunis, Eduardo; Van Thiel, David H.; Starzl, Thomas E.

In: Journal of Pediatric Surgery, Vol. 28, No. 8, 1993, p. 1040-1043.

Research output: Contribution to journalArticle

Tzakis, AG, Todo, S, Reyes, J, Nour, B, Abu-Elmagd, K, Selby, R, Casavilla, A, Kocoshis, S, Demetris, AJ, Yunis, E, Van Thiel, DH & Starzl, TE 1993, 'Intestinal transplantation in children under FK 506 immunosuppression', Journal of Pediatric Surgery, vol. 28, no. 8, pp. 1040-1043. https://doi.org/10.1016/0022-3468(93)90514-L
Tzakis, Andreas G. ; Todo, Satoru ; Reyes, Jorge ; Nour, Bakr ; Abu-Elmagd, Kareem ; Selby, Rick ; Casavilla, Adrian ; Kocoshis, Samuel ; Demetris, Anthony J. ; Yunis, Eduardo ; Van Thiel, David H. ; Starzl, Thomas E. / Intestinal transplantation in children under FK 506 immunosuppression. In: Journal of Pediatric Surgery. 1993 ; Vol. 28, No. 8. pp. 1040-1043.
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