Intestinal transplantation in children under FK 506 immunosuppression

Andreas G. Tzakis, Satoru Todo, Jorge Reyes, Bakr Nour, Kareem Abu-Elmagd, Rick Selby, Adrian Casavilla, Samuel Kocoshis, Anthony J. Demetris, Eduardo Yunis, David H. Van Thiel, Thomas E. Starzl

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Intestinal transplantation, solitary (n = 3) or in combination with the liver (n = 7), was performed in 10 pediatric patients with intestinal failure. The liver was only replaced if there was liver failure and portal hypertension. Immunosuppression was based on FK 506. Two patients died, one of graft-versus-host disease and one of lymphoproliferative disease. One patient was still in the intensive care unit 1 month posttransplantation due to perioperative complications. The function of the intestinal grafts in the remaining patients is normal. All nutrition and medications including immunosuppression are being administered enterally. This series indicates that small bowel transplantation, alone or in combination with the liver, is feasible in pediatric patients.

Original languageEnglish
Pages (from-to)1040-1043
Number of pages4
JournalJournal of Pediatric Surgery
Volume28
Issue number8
DOIs
Publication statusPublished - Aug 1993

Keywords

  • FK 506 immunosuppression
  • Intestinal transplantation
  • liver transplantation

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Intestinal transplantation in children under FK 506 immunosuppression'. Together they form a unique fingerprint.

  • Cite this

    Tzakis, A. G., Todo, S., Reyes, J., Nour, B., Abu-Elmagd, K., Selby, R., Casavilla, A., Kocoshis, S., Demetris, A. J., Yunis, E., Van Thiel, D. H., & Starzl, T. E. (1993). Intestinal transplantation in children under FK 506 immunosuppression. Journal of Pediatric Surgery, 28(8), 1040-1043. https://doi.org/10.1016/0022-3468(93)90514-L