Intestinal Calcium Absorption Is Associated with Bone Mass in Stone-Forming Women with Idiopathic Hypercalciuria

Giuseppe Vezzoli, Alessandro Rubinacci, Cristiana Bianchin, Teresa Arcidiacono, Salvatore Giambona, Giovanna Mignogna, Elena Fochesato, Annalisa Terranegra, Daniele Cusi, Laura Soldati

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Patients with idiopathic hypercalciuria are predisposed to osteoporosis despite their high enteral calcium absorption. Conversely, low calcium absorption has been reported in patients with osteoporosis. Because bone loss occurs earlier in women, this work explores the relationship between bone mineral density (BMD) and calcium absorption in premenopausal and postmenopausal hypercalciuric stone-forming women. Methods: BMD and intestinal calcium absorption were compared in 64 hypercalciuric and 42 normocalciuric calcium stone-forming women. Calcium absorption was assessed by using strontium as a surrogate marker for calcium. Strontium was administered to patients as an oral load, then measured in blood to calculate absorption after 60 minutes. Femoral and lumbar-spine BMD were measured by dual-energy x-ray absorptiometry. Results: Strontium absorption was significantly increased in hypercalciuric stone formers, whereas BMD z score was decreased in hypercalciuric patients at the lumbar spine, but not the femur. The increase in strontium absorption was detected in both postmenopausal (n = 29) and premenopausal (n = 35) hypercalciuric patients. The decrease in lumbar-spine BMD was confirmed in postmenopausal, but not premenopausal, hypercalciuric patients. Strontium absorption was greater in hypercalciuric patients with a lumbar-spine BMD z score of -2 or less (n = 10) than in those with a score greater than -2 (n = 54). Multiple stepwise regression showed that lumbar-spine BMD was related negatively to intestinal strontium absorption and age in hypercalciuric patients. Conclusion: Results of the strontium absorption test suggest that the increase in calcium absorption is associated with a decrease in lumbar-spine BMD in hypercalciuric stone-forming women. Hypercalciuric stone-forming women with high calcium intestinal absorption denote a group of patients predisposed to loss of bone mass.

Original languageEnglish
Pages (from-to)1177-1183
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume42
Issue number6
DOIs
Publication statusPublished - Dec 2003
Externally publishedYes

Fingerprint

Hypercalciuria
Intestinal Absorption
Strontium
Bone Density
Calcium
Bone and Bones
Spine
Osteoporosis
Thigh
Femur
Small Intestine
Biomarkers
X-Rays

Keywords

  • Hypercalciuria
  • Intestinal calcium absorption
  • Osteoporosis
  • Strontium metabolism

ASJC Scopus subject areas

  • Nephrology

Cite this

Vezzoli, G., Rubinacci, A., Bianchin, C., Arcidiacono, T., Giambona, S., Mignogna, G., ... Soldati, L. (2003). Intestinal Calcium Absorption Is Associated with Bone Mass in Stone-Forming Women with Idiopathic Hypercalciuria. American Journal of Kidney Diseases, 42(6), 1177-1183. https://doi.org/10.1053/j.ajkd.2003.08.018

Intestinal Calcium Absorption Is Associated with Bone Mass in Stone-Forming Women with Idiopathic Hypercalciuria. / Vezzoli, Giuseppe; Rubinacci, Alessandro; Bianchin, Cristiana; Arcidiacono, Teresa; Giambona, Salvatore; Mignogna, Giovanna; Fochesato, Elena; Terranegra, Annalisa; Cusi, Daniele; Soldati, Laura.

In: American Journal of Kidney Diseases, Vol. 42, No. 6, 12.2003, p. 1177-1183.

Research output: Contribution to journalArticle

Vezzoli, G, Rubinacci, A, Bianchin, C, Arcidiacono, T, Giambona, S, Mignogna, G, Fochesato, E, Terranegra, A, Cusi, D & Soldati, L 2003, 'Intestinal Calcium Absorption Is Associated with Bone Mass in Stone-Forming Women with Idiopathic Hypercalciuria', American Journal of Kidney Diseases, vol. 42, no. 6, pp. 1177-1183. https://doi.org/10.1053/j.ajkd.2003.08.018
Vezzoli, Giuseppe ; Rubinacci, Alessandro ; Bianchin, Cristiana ; Arcidiacono, Teresa ; Giambona, Salvatore ; Mignogna, Giovanna ; Fochesato, Elena ; Terranegra, Annalisa ; Cusi, Daniele ; Soldati, Laura. / Intestinal Calcium Absorption Is Associated with Bone Mass in Stone-Forming Women with Idiopathic Hypercalciuria. In: American Journal of Kidney Diseases. 2003 ; Vol. 42, No. 6. pp. 1177-1183.
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AU - Bianchin, Cristiana

AU - Arcidiacono, Teresa

AU - Giambona, Salvatore

AU - Mignogna, Giovanna

AU - Fochesato, Elena

AU - Terranegra, Annalisa

AU - Cusi, Daniele

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N2 - Background: Patients with idiopathic hypercalciuria are predisposed to osteoporosis despite their high enteral calcium absorption. Conversely, low calcium absorption has been reported in patients with osteoporosis. Because bone loss occurs earlier in women, this work explores the relationship between bone mineral density (BMD) and calcium absorption in premenopausal and postmenopausal hypercalciuric stone-forming women. Methods: BMD and intestinal calcium absorption were compared in 64 hypercalciuric and 42 normocalciuric calcium stone-forming women. Calcium absorption was assessed by using strontium as a surrogate marker for calcium. Strontium was administered to patients as an oral load, then measured in blood to calculate absorption after 60 minutes. Femoral and lumbar-spine BMD were measured by dual-energy x-ray absorptiometry. Results: Strontium absorption was significantly increased in hypercalciuric stone formers, whereas BMD z score was decreased in hypercalciuric patients at the lumbar spine, but not the femur. The increase in strontium absorption was detected in both postmenopausal (n = 29) and premenopausal (n = 35) hypercalciuric patients. The decrease in lumbar-spine BMD was confirmed in postmenopausal, but not premenopausal, hypercalciuric patients. Strontium absorption was greater in hypercalciuric patients with a lumbar-spine BMD z score of -2 or less (n = 10) than in those with a score greater than -2 (n = 54). Multiple stepwise regression showed that lumbar-spine BMD was related negatively to intestinal strontium absorption and age in hypercalciuric patients. Conclusion: Results of the strontium absorption test suggest that the increase in calcium absorption is associated with a decrease in lumbar-spine BMD in hypercalciuric stone-forming women. Hypercalciuric stone-forming women with high calcium intestinal absorption denote a group of patients predisposed to loss of bone mass.

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