Intervention in biological phenomena via feedback linearization

Mohamed Amine Fnaiech, Hazem Nounou, Mohamed Nounou, Aniruddha Datta

Research output: Contribution to journalArticle

Abstract

The problems of modeling and intervention of biological phenomena have captured the interest of many researchers in the past few decades. The aim of the therapeutic intervention strategies is to move an undesirable state of a diseased network towards a more desirable one. Such an objective can be achieved by the application of drugs to act on some genes/metabolites that experience the undesirable behavior. For the purpose of design and analysis of intervention strategies, mathematical models that can capture the complex dynamics of the biological systems are needed. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of biological phenomena. Due to the complex nonlinear dynamics of the biological phenomena represented by S-systems, nonlinear intervention schemes are needed to cope with the complexity of the nonlinear S-system models. Here, we present an intervention technique based on feedback linearization for biological phenomena modeled by S-systems. This technique is based on perfect knowledge of the S-system model. The proposed intervention technique is applied to the glycolytic-glycogenolytic pathway, and simulation results presented demonstrate the effectiveness of the proposed technique.

Original languageEnglish
Article number534810
JournalAdvances in Bioinformatics
Volume2012
DOIs
Publication statusPublished - 2012

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ASJC Scopus subject areas

  • Biomedical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Computer Science Applications

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