Intervention in biological phenomena modeled by S-systems: A model predictive control approach

N. Meskin, Hazem Nounou, Mohamed Nounou, A. Datta, E. R. Dougherty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent years have witnessed extensive research activity in modeling genetic regulatory networks (GRNs) as well as in developing therapeutic intervention strategies for such networks. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of GRNs, as well as that of biochemical pathways. In this paper, an intervention strategy is proposed for the S-system model. In this approach, a model predictive control algorithm is developed which guides the target variables to their desired values. The proposed intervention strategy is applied to the glycolytic-glycogenolytic pathway as well as a generic branched pathway and the simulation results presented demonstrate the effectiveness of the proposed scheme.

Original languageEnglish
Title of host publicationProceedings of the 2011 American Control Conference, ACC 2011
Pages3519-3523
Number of pages5
Publication statusPublished - 2011
Event2011 American Control Conference, ACC 2011 - San Francisco, CA, United States
Duration: 29 Jun 20111 Jul 2011

Other

Other2011 American Control Conference, ACC 2011
CountryUnited States
CitySan Francisco, CA
Period29/6/111/7/11

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Meskin, N., Nounou, H., Nounou, M., Datta, A., & Dougherty, E. R. (2011). Intervention in biological phenomena modeled by S-systems: A model predictive control approach. In Proceedings of the 2011 American Control Conference, ACC 2011 (pp. 3519-3523). [5990875]