Interspecific variation of olfactory preferences in flies, mice, and humans

Diogo Manoel, Melanie Makhlouf, Antonio Scialdone, Luis Miguel Rodrigues Saraiva

Research output: Contribution to journalArticle


Aiming to unravel interspecific differences in olfactory preferences, we performed comparative studies of odor valence in flies, mice, and humans. Our analysis suggests a model where flies and mice share similar olfactory preferences, but neither species share odor preferences with humans. This model contrasts with a previous study by Mandairon et al., which suggested that the olfactory preferences of mice and humans are similar. A probabilistic examination revealed that underpowered studies can result in spurious significant correlations, which can account for the differences between both studies. Future analyses aimed at dissecting the olfactory preferences across species need to test large numbers of odorants to stress-test the model proposed here and identify robust associations.

Original languageEnglish
Pages (from-to)7-9
Number of pages3
JournalChemical Senses
Issue number1
Publication statusPublished - 1 Jan 2019


ASJC Scopus subject areas

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience

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