Interleukin-18 and diabetic nephropathy

A review

Habib Yaribeygi, Stephen Atkin, Amirhossein Sahebkar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediators such as interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-α, and macrophage chemotactic protein-1; however, the role of IL-18 seems to be more specific than other cytokines in the inflammatory process. IL-18 is expressed in renal tissue and is upregulated by several stimuli including hyperglycemia. The expression/urinary level of IL-18 is positively correlated with the progression of diabetic nephropathy and the urinary albumin excretion rate. In this review, we have focused on the molecular pathways modulating the relationship between IL-18 and diabetic nephropathy.

Original languageEnglish
JournalJournal of Cellular Physiology
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

Interleukin-18
Diabetic Nephropathies
Macrophages
Interleukin-1
Hyperglycemia
Albumins
Interleukin-6
Tumor Necrosis Factor-alpha
Tissue
Cytokines
Kidney
Proteins

Keywords

  • apoptosis
  • diabetic nephropathy
  • inflammatory response
  • interleukin-18
  • oxidative stress
  • tumor necrosis factor-α

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Interleukin-18 and diabetic nephropathy : A review. / Yaribeygi, Habib; Atkin, Stephen; Sahebkar, Amirhossein.

In: Journal of Cellular Physiology, 01.01.2018.

Research output: Contribution to journalArticle

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