Interleukin-10 and interferon-gamma gene polymorphisms in patients with nasopharyngeal carcinoma

K. Farhat, E. Hassen, S. Gabbouj, N. Bouaouina, Lotfi Chouchane

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Nasopharyngeal carcinoma (NPC) is a multifactorial disease. Cytokines driving the immune response seem to be disturbed in NPC patients. Since interleukin-10 (IL-10) is known to reduce the production of interferon-gamma (IFN-γ), we supposed that genetic differences in IL-10 and IFN-γ expression could be a mechanism by which NPC cells escape antitumour immune response. As the production of each cytokine is affected by the genetic background, we investigated the possible association between single nucleotide polymorphisms in genes of IL-10 and IFN-γ with NPC. Different IL-10 -1082 G/A and IFN-γ +874 Τ/Α genotypes were determined in 160 patients with nasopharyngeal carcinoma and 197 healthy controls. No association was found either for each SNP studied alone or for the combined analysis for both IL-10 and IFN-γ polymorphisms among NPC patients in comparison with controls. Compared with individuals from high incidence countries, we noted huge significant differences in genotype distribution between individuals from low and intermediate NPC incidence countries. Polymorphisms of the IL-10 and IFN-γ do not appear to be associated with NPC risk in the Tunisian population. Nevertheless, we strongly believe that the relationship between cytokines polymorphisms and NPC susceptibility deeply depends on the ethnicity.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalInternational Journal of Immunogenetics
Volume35
Issue number3
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Interleukin-10
Interferon-gamma
Genes
Cytokines
Single Nucleotide Polymorphism
Genotype
Nasopharyngeal carcinoma
Incidence
Population

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Interleukin-10 and interferon-gamma gene polymorphisms in patients with nasopharyngeal carcinoma. / Farhat, K.; Hassen, E.; Gabbouj, S.; Bouaouina, N.; Chouchane, Lotfi.

In: International Journal of Immunogenetics, Vol. 35, No. 3, 06.2008, p. 197-205.

Research output: Contribution to journalArticle

@article{0f3662c7e0a84ce1ad6c86ab878438f7,
title = "Interleukin-10 and interferon-gamma gene polymorphisms in patients with nasopharyngeal carcinoma",
abstract = "Nasopharyngeal carcinoma (NPC) is a multifactorial disease. Cytokines driving the immune response seem to be disturbed in NPC patients. Since interleukin-10 (IL-10) is known to reduce the production of interferon-gamma (IFN-γ), we supposed that genetic differences in IL-10 and IFN-γ expression could be a mechanism by which NPC cells escape antitumour immune response. As the production of each cytokine is affected by the genetic background, we investigated the possible association between single nucleotide polymorphisms in genes of IL-10 and IFN-γ with NPC. Different IL-10 -1082 G/A and IFN-γ +874 Τ/Α genotypes were determined in 160 patients with nasopharyngeal carcinoma and 197 healthy controls. No association was found either for each SNP studied alone or for the combined analysis for both IL-10 and IFN-γ polymorphisms among NPC patients in comparison with controls. Compared with individuals from high incidence countries, we noted huge significant differences in genotype distribution between individuals from low and intermediate NPC incidence countries. Polymorphisms of the IL-10 and IFN-γ do not appear to be associated with NPC risk in the Tunisian population. Nevertheless, we strongly believe that the relationship between cytokines polymorphisms and NPC susceptibility deeply depends on the ethnicity.",
author = "K. Farhat and E. Hassen and S. Gabbouj and N. Bouaouina and Lotfi Chouchane",
year = "2008",
month = "6",
doi = "10.1111/j.1744-313X.2008.00752.x",
language = "English",
volume = "35",
pages = "197--205",
journal = "International Journal of Immunogenetics",
issn = "1744-3121",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Interleukin-10 and interferon-gamma gene polymorphisms in patients with nasopharyngeal carcinoma

AU - Farhat, K.

AU - Hassen, E.

AU - Gabbouj, S.

AU - Bouaouina, N.

AU - Chouchane, Lotfi

PY - 2008/6

Y1 - 2008/6

N2 - Nasopharyngeal carcinoma (NPC) is a multifactorial disease. Cytokines driving the immune response seem to be disturbed in NPC patients. Since interleukin-10 (IL-10) is known to reduce the production of interferon-gamma (IFN-γ), we supposed that genetic differences in IL-10 and IFN-γ expression could be a mechanism by which NPC cells escape antitumour immune response. As the production of each cytokine is affected by the genetic background, we investigated the possible association between single nucleotide polymorphisms in genes of IL-10 and IFN-γ with NPC. Different IL-10 -1082 G/A and IFN-γ +874 Τ/Α genotypes were determined in 160 patients with nasopharyngeal carcinoma and 197 healthy controls. No association was found either for each SNP studied alone or for the combined analysis for both IL-10 and IFN-γ polymorphisms among NPC patients in comparison with controls. Compared with individuals from high incidence countries, we noted huge significant differences in genotype distribution between individuals from low and intermediate NPC incidence countries. Polymorphisms of the IL-10 and IFN-γ do not appear to be associated with NPC risk in the Tunisian population. Nevertheless, we strongly believe that the relationship between cytokines polymorphisms and NPC susceptibility deeply depends on the ethnicity.

AB - Nasopharyngeal carcinoma (NPC) is a multifactorial disease. Cytokines driving the immune response seem to be disturbed in NPC patients. Since interleukin-10 (IL-10) is known to reduce the production of interferon-gamma (IFN-γ), we supposed that genetic differences in IL-10 and IFN-γ expression could be a mechanism by which NPC cells escape antitumour immune response. As the production of each cytokine is affected by the genetic background, we investigated the possible association between single nucleotide polymorphisms in genes of IL-10 and IFN-γ with NPC. Different IL-10 -1082 G/A and IFN-γ +874 Τ/Α genotypes were determined in 160 patients with nasopharyngeal carcinoma and 197 healthy controls. No association was found either for each SNP studied alone or for the combined analysis for both IL-10 and IFN-γ polymorphisms among NPC patients in comparison with controls. Compared with individuals from high incidence countries, we noted huge significant differences in genotype distribution between individuals from low and intermediate NPC incidence countries. Polymorphisms of the IL-10 and IFN-γ do not appear to be associated with NPC risk in the Tunisian population. Nevertheless, we strongly believe that the relationship between cytokines polymorphisms and NPC susceptibility deeply depends on the ethnicity.

UR - http://www.scopus.com/inward/record.url?scp=43549109291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43549109291&partnerID=8YFLogxK

U2 - 10.1111/j.1744-313X.2008.00752.x

DO - 10.1111/j.1744-313X.2008.00752.x

M3 - Article

C2 - 18312596

AN - SCOPUS:43549109291

VL - 35

SP - 197

EP - 205

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

SN - 1744-3121

IS - 3

ER -