Interactions of the circadian CLOCK system and the HPA axis

Nancy Nader, George P. Chrousos, Tomoshige Kino

Research output: Contribution to journalReview article

193 Citations (Scopus)

Abstract

Organisms have developed concurrent behavioral and physiological adaptations to the strong influence of day/night cycles, as well as to unforeseen, random stress stimuli. These circadian and stress-related responses are achieved by two highly conserved and interrelated regulatory networks, the circadian CLOCK and stress systems, which respectively consist of oscillating molecular pacemakers, the Clock/Bmal1 transcription factors, and the hypothalamic-pituitary-adrenal (HPA) axis and its end-effector, the glucocorticoid receptor. These systems communicate with one another at different signaling levels and dysregulation of either system can lead to development of pathologic conditions. In this review, we summarize the mutual physiologic interactions between the circadian CLOCK system and the HPA axis, and discuss their clinical implications.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalTrends in Endocrinology and Metabolism
Volume21
Issue number5
DOIs
Publication statusPublished - May 2010
Externally publishedYes

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Pituitary-Adrenal System
Physiological Adaptation
Glucocorticoid Receptors
Transcription Factors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Interactions of the circadian CLOCK system and the HPA axis. / Nader, Nancy; Chrousos, George P.; Kino, Tomoshige.

In: Trends in Endocrinology and Metabolism, Vol. 21, No. 5, 05.2010, p. 277-286.

Research output: Contribution to journalReview article

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