Interactions of multiple strain pathogen diseases in the presence of coinfection, cross immunity, and arbitrary strain diversity

Laith Aburaddad, B. I S Van Der Ventel, N. M. Ferguson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A model for coinfection in multiple strain infectious diseases is developed to incorporate coinfection statuses, immune and infection history, and cross immunity. It is solved for the symmetric interior equilibrium through the use of a ladder operator formalism inspired by quantum mechanical methods. We find that coinfection can fundamentally affects transmission dynamics with important epidemiologic and evolutionary consequences. It can significantly shift the distribution of age at infection for highly antigenically diverse pathogens so that in small host populations, an evolutionary strategy maximizing individual strain transmissibility might be less optimal than one which maximizes the total prevalence of all strains in the system. Alternatively, mechanisms which inhibit coinfection and thus increase total infection prevalence may be evolutionarily advantageous.

Original languageEnglish
Article number168102
JournalPhysical Review Letters
Volume100
Issue number16
DOIs
Publication statusPublished - 23 Apr 2008
Externally publishedYes

Fingerprint

pathogens
immunity
infectious diseases
Coinfection
Immunity
interactions
Age Distribution
Cross Infection
Infection
ladders
Communicable Diseases
History
histories
formalism
operators
shift
Population

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Interactions of multiple strain pathogen diseases in the presence of coinfection, cross immunity, and arbitrary strain diversity. / Aburaddad, Laith; Van Der Ventel, B. I S; Ferguson, N. M.

In: Physical Review Letters, Vol. 100, No. 16, 168102, 23.04.2008.

Research output: Contribution to journalArticle

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