Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease

A nutrigenetic observational study

Federica Rizzi, Costanza Conti, Elena Dogliotti, Annalisa Terranegra, Erika Salvi, Daniele Braga, Flavia Ricca, Sara Lupoli, Alessandra Mingione, Francesca Pivari, Caterina Brasacchio, Matteo Barcella, Martina Chittani, Francesca D'Avila, Maurizio Turiel, Monica Lazzaroni, Laura Soldati, Daniele Cusi, Cristina Barlassina

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population. Methods: We recruited 443 healthy volunteers who participated in the EC funded ATHENA project (AnThocyanin and polyphenols bioactive for Health Enhancement through Nutritional Advancement). Data collection included detailed demographic, clinical, dietary, lifestyle, biochemical and genetic data. Polyphenols and anthocyanins intake was measured by 24h dietary recall repeated three times a year in order to get seasonal variations. We tested the interaction between 18 independent tagging SNPs in PON1 gene and polyphenols intake on HDL, LDL, cholesterol, triglycerides and atherogenic index of plasma. Results: Without considering the genetic background, we could not observe significant differences in the lipid profile between high and low polyphenols and anthocyanins intake. Using a nutrigenetic approach, we identified protective genotypes in four independent polymorphisms that, at Bonferroni level (p≤0.0028), present a significant association with increased HDL level under high polyphenols and anthocyanins intake, compared to risk genotypes (rs854549, Beta=4.7 per C allele; rs854552, Beta=5.6 per C allele; rs854571, Beta=3.92 per T allele; rs854572, Beta=3.94 per C allele). Conclusions: We highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption. PON1 variants could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine.

Original languageEnglish
Article number186
JournalJournal of Translational Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - 23 Jun 2016

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Nutrigenomics
Aryldialkylphosphatase
Polyphenols
Observational Studies
Anthocyanins
Cardiovascular Diseases
Genes
Alleles
Health
Biomarkers
Polymorphism
Genotype
Lipids
Preventive Medicine
Health Promotion
LDL Cholesterol
HDL Cholesterol
Medicine
Single Nucleotide Polymorphism
Life Style

Keywords

  • Anthocyanins
  • Antioxidants
  • Gene diet interaction
  • Genetic variants
  • HDL
  • Lipid profile
  • Nutrigenomics
  • Polyphenols
  • PON1 gene

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease : A nutrigenetic observational study. / Rizzi, Federica; Conti, Costanza; Dogliotti, Elena; Terranegra, Annalisa; Salvi, Erika; Braga, Daniele; Ricca, Flavia; Lupoli, Sara; Mingione, Alessandra; Pivari, Francesca; Brasacchio, Caterina; Barcella, Matteo; Chittani, Martina; D'Avila, Francesca; Turiel, Maurizio; Lazzaroni, Monica; Soldati, Laura; Cusi, Daniele; Barlassina, Cristina.

In: Journal of Translational Medicine, Vol. 14, No. 1, 186, 23.06.2016.

Research output: Contribution to journalArticle

Rizzi, F, Conti, C, Dogliotti, E, Terranegra, A, Salvi, E, Braga, D, Ricca, F, Lupoli, S, Mingione, A, Pivari, F, Brasacchio, C, Barcella, M, Chittani, M, D'Avila, F, Turiel, M, Lazzaroni, M, Soldati, L, Cusi, D & Barlassina, C 2016, 'Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: A nutrigenetic observational study', Journal of Translational Medicine, vol. 14, no. 1, 186. https://doi.org/10.1186/s12967-016-0941-6
Rizzi, Federica ; Conti, Costanza ; Dogliotti, Elena ; Terranegra, Annalisa ; Salvi, Erika ; Braga, Daniele ; Ricca, Flavia ; Lupoli, Sara ; Mingione, Alessandra ; Pivari, Francesca ; Brasacchio, Caterina ; Barcella, Matteo ; Chittani, Martina ; D'Avila, Francesca ; Turiel, Maurizio ; Lazzaroni, Monica ; Soldati, Laura ; Cusi, Daniele ; Barlassina, Cristina. / Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease : A nutrigenetic observational study. In: Journal of Translational Medicine. 2016 ; Vol. 14, No. 1.
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abstract = "Background: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population. Methods: We recruited 443 healthy volunteers who participated in the EC funded ATHENA project (AnThocyanin and polyphenols bioactive for Health Enhancement through Nutritional Advancement). Data collection included detailed demographic, clinical, dietary, lifestyle, biochemical and genetic data. Polyphenols and anthocyanins intake was measured by 24h dietary recall repeated three times a year in order to get seasonal variations. We tested the interaction between 18 independent tagging SNPs in PON1 gene and polyphenols intake on HDL, LDL, cholesterol, triglycerides and atherogenic index of plasma. Results: Without considering the genetic background, we could not observe significant differences in the lipid profile between high and low polyphenols and anthocyanins intake. Using a nutrigenetic approach, we identified protective genotypes in four independent polymorphisms that, at Bonferroni level (p≤0.0028), present a significant association with increased HDL level under high polyphenols and anthocyanins intake, compared to risk genotypes (rs854549, Beta=4.7 per C allele; rs854552, Beta=5.6 per C allele; rs854571, Beta=3.92 per T allele; rs854572, Beta=3.94 per C allele). Conclusions: We highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption. PON1 variants could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine.",
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T2 - A nutrigenetic observational study

AU - Rizzi, Federica

AU - Conti, Costanza

AU - Dogliotti, Elena

AU - Terranegra, Annalisa

AU - Salvi, Erika

AU - Braga, Daniele

AU - Ricca, Flavia

AU - Lupoli, Sara

AU - Mingione, Alessandra

AU - Pivari, Francesca

AU - Brasacchio, Caterina

AU - Barcella, Matteo

AU - Chittani, Martina

AU - D'Avila, Francesca

AU - Turiel, Maurizio

AU - Lazzaroni, Monica

AU - Soldati, Laura

AU - Cusi, Daniele

AU - Barlassina, Cristina

PY - 2016/6/23

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N2 - Background: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population. Methods: We recruited 443 healthy volunteers who participated in the EC funded ATHENA project (AnThocyanin and polyphenols bioactive for Health Enhancement through Nutritional Advancement). Data collection included detailed demographic, clinical, dietary, lifestyle, biochemical and genetic data. Polyphenols and anthocyanins intake was measured by 24h dietary recall repeated three times a year in order to get seasonal variations. We tested the interaction between 18 independent tagging SNPs in PON1 gene and polyphenols intake on HDL, LDL, cholesterol, triglycerides and atherogenic index of plasma. Results: Without considering the genetic background, we could not observe significant differences in the lipid profile between high and low polyphenols and anthocyanins intake. Using a nutrigenetic approach, we identified protective genotypes in four independent polymorphisms that, at Bonferroni level (p≤0.0028), present a significant association with increased HDL level under high polyphenols and anthocyanins intake, compared to risk genotypes (rs854549, Beta=4.7 per C allele; rs854552, Beta=5.6 per C allele; rs854571, Beta=3.92 per T allele; rs854572, Beta=3.94 per C allele). Conclusions: We highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption. PON1 variants could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine.

AB - Background: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population. Methods: We recruited 443 healthy volunteers who participated in the EC funded ATHENA project (AnThocyanin and polyphenols bioactive for Health Enhancement through Nutritional Advancement). Data collection included detailed demographic, clinical, dietary, lifestyle, biochemical and genetic data. Polyphenols and anthocyanins intake was measured by 24h dietary recall repeated three times a year in order to get seasonal variations. We tested the interaction between 18 independent tagging SNPs in PON1 gene and polyphenols intake on HDL, LDL, cholesterol, triglycerides and atherogenic index of plasma. Results: Without considering the genetic background, we could not observe significant differences in the lipid profile between high and low polyphenols and anthocyanins intake. Using a nutrigenetic approach, we identified protective genotypes in four independent polymorphisms that, at Bonferroni level (p≤0.0028), present a significant association with increased HDL level under high polyphenols and anthocyanins intake, compared to risk genotypes (rs854549, Beta=4.7 per C allele; rs854552, Beta=5.6 per C allele; rs854571, Beta=3.92 per T allele; rs854572, Beta=3.94 per C allele). Conclusions: We highlight the protective role of genetic variants in PON1 towards cardiovascular risk under high polyphenols and anthocyanins consumption. PON1 variants could represent novel biomarkers to stratify individuals who might benefit from targeted dietary recommendation for health promotion and strategies of preventive medicine.

KW - Anthocyanins

KW - Antioxidants

KW - Gene diet interaction

KW - Genetic variants

KW - HDL

KW - Lipid profile

KW - Nutrigenomics

KW - Polyphenols

KW - PON1 gene

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