Abstract
Introduction: As the impact of diabetes control was not tested on adiponectin (ADPN) levels, this study was designed to assess whether or not controlling hyperglycaemia can affect ADPN. Patients and methods: A total of 15 T1D and 48 T2D patients with HbA1c greater than 10% were studied at the time of hospitalization for uncontrolled diabetes. Total, and high-, medium- and low-molecular-weight (HMW, MMW, LMW) ADPN were measured at the time of study inclusion, on days 1 and 8, and at 1, 3 and 6months after insulin treatment. Results: While diabetes control improved, total and HMW APDN decreased on days 1 and 8, but remained steady thereafter in T2D patients. In T1D patients, ADPN levels remained unchanged throughout the study. Conclusion: Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D.
| Original language | English |
|---|---|
| Pages (from-to) | 259-261 |
| Number of pages | 3 |
| Journal | Diabetes and Metabolism |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2011 |
| Externally published | Yes |
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Keywords
- Adiponectin
- Glycaemic control
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2, but not in type 1, diabetes. / Abi Khalil, Charbel; Mohammedi, K.; Aubert, R.; Travert, F.; Hadjadj, S.; Roussel, R.; Fumeron, F.; Marre, M.
In: Diabetes and Metabolism, Vol. 37, No. 3, 06.2011, p. 259-261.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2, but not in type 1, diabetes
AU - Abi Khalil, Charbel
AU - Mohammedi, K.
AU - Aubert, R.
AU - Travert, F.
AU - Hadjadj, S.
AU - Roussel, R.
AU - Fumeron, F.
AU - Marre, M.
PY - 2011/6
Y1 - 2011/6
N2 - Introduction: As the impact of diabetes control was not tested on adiponectin (ADPN) levels, this study was designed to assess whether or not controlling hyperglycaemia can affect ADPN. Patients and methods: A total of 15 T1D and 48 T2D patients with HbA1c greater than 10% were studied at the time of hospitalization for uncontrolled diabetes. Total, and high-, medium- and low-molecular-weight (HMW, MMW, LMW) ADPN were measured at the time of study inclusion, on days 1 and 8, and at 1, 3 and 6months after insulin treatment. Results: While diabetes control improved, total and HMW APDN decreased on days 1 and 8, but remained steady thereafter in T2D patients. In T1D patients, ADPN levels remained unchanged throughout the study. Conclusion: Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D.
AB - Introduction: As the impact of diabetes control was not tested on adiponectin (ADPN) levels, this study was designed to assess whether or not controlling hyperglycaemia can affect ADPN. Patients and methods: A total of 15 T1D and 48 T2D patients with HbA1c greater than 10% were studied at the time of hospitalization for uncontrolled diabetes. Total, and high-, medium- and low-molecular-weight (HMW, MMW, LMW) ADPN were measured at the time of study inclusion, on days 1 and 8, and at 1, 3 and 6months after insulin treatment. Results: While diabetes control improved, total and HMW APDN decreased on days 1 and 8, but remained steady thereafter in T2D patients. In T1D patients, ADPN levels remained unchanged throughout the study. Conclusion: Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D.
KW - Adiponectin
KW - Glycaemic control
KW - Type 1 diabetes mellitus
KW - Type 2 diabetes mellitus
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U2 - 10.1016/j.diabet.2010.12.001
DO - 10.1016/j.diabet.2010.12.001
M3 - Article
VL - 37
SP - 259
EP - 261
JO - Diabetes and Metabolism
JF - Diabetes and Metabolism
SN - 1262-3636
IS - 3
ER -