Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2, but not in type 1, diabetes

Charbel Abi Khalil, K. Mohammedi, R. Aubert, F. Travert, S. Hadjadj, R. Roussel, F. Fumeron, M. Marre

Research output: Contribution to journalArticle

4 Citations (Scopus)


Introduction: As the impact of diabetes control was not tested on adiponectin (ADPN) levels, this study was designed to assess whether or not controlling hyperglycaemia can affect ADPN. Patients and methods: A total of 15 T1D and 48 T2D patients with HbA1c greater than 10% were studied at the time of hospitalization for uncontrolled diabetes. Total, and high-, medium- and low-molecular-weight (HMW, MMW, LMW) ADPN were measured at the time of study inclusion, on days 1 and 8, and at 1, 3 and 6months after insulin treatment. Results: While diabetes control improved, total and HMW APDN decreased on days 1 and 8, but remained steady thereafter in T2D patients. In T1D patients, ADPN levels remained unchanged throughout the study. Conclusion: Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D.

Original languageEnglish
Pages (from-to)259-261
Number of pages3
JournalDiabetes and Metabolism
Issue number3
Publication statusPublished - Jun 2011
Externally publishedYes



  • Adiponectin
  • Glycaemic control
  • Type 1 diabetes mellitus
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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