Insulin and hypertension in the NHLBI family heart study

Florian Kronenberg, Stephen S. Rich, Phyliss Sholinsky, Donna K. Arnett, Michael E. Province, Richard H. Myers, John H. Eckfeldt, Roger R. Williams, Steven Hunt

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The association between insulin and hypertension remains equivocal. We therefore investigated insulin levels in 3037 normotensive and 1067 hypertensive subjects from the National Heart, Lung and Blood Institute (NHLBI) Family Heart Study (FHS) by two different approaches. First, we compared insulin levels between normotensive and 275 untreated hypertensive subjects. Insulin levels unadjusted as well as adjusted for age, sex, and center were significantly higher in hypertensives. After adjustment for body mass index (BMI), insulin remained significantly higher only in the diastolic hypertensive group (mean ± SD 77.0 ± 36.7 pmol/L, P < .01) but not in the isolated systolic hypertensive group (67.0 ± 38.2 pmol/L) when compared to normotensives (63.2 ± 29.1 pmol/L). A sibpair analysis was then used that compared the intra-sibpair differences in insulin concentrations to the intra-sibpair differences in blood pressure (BP) levels. This approach was intended to control for the effects of genetic and residual shared environmental variance upon insulin levels. The intra-sibpair difference in insulin concentrations between concordant (diastolic and systolic ΔBP < 5 mm Hg) and discordant sibpairs (diastolic and systolic ΔBP > 15 and > 20 mm Hg, respectively) was no longer significantly different when adjusted for BMI (2.7 v 5.9 pmol/L for diastolic and -1.7 v -1.8 pmol/L for systolic BP). Even the random selection of one sibpair from each of the 326 families independently of insulin and BP levels did not result in a significant correlation between the intra-sibpair differences in insulin and BP. Using an insulin resistance index instead of insulin did not change our findings. Our investigation in the FHS sample of families suggests that there is only a small, if any, influence of insulin levels on BP after adjustment for obesity-related sources of variation. (C) 2000 American Journal of Hypertension, Ltd.

Original languageEnglish
Pages (from-to)240-250
Number of pages11
JournalAmerican Journal of Hypertension
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 2000
Externally publishedYes

Fingerprint

National Heart, Lung, and Blood Institute (U.S.)
Insulin
Hypertension
Body Mass Index
Insulin Resistance
Obesity

Keywords

  • Body mass index
  • Hypertension
  • Insulin
  • Obesity
  • Sibpair study

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kronenberg, F., Rich, S. S., Sholinsky, P., Arnett, D. K., Province, M. E., Myers, R. H., ... Hunt, S. (2000). Insulin and hypertension in the NHLBI family heart study. American Journal of Hypertension, 13(3), 240-250. https://doi.org/10.1016/S0895-7061(99)00177-6

Insulin and hypertension in the NHLBI family heart study. / Kronenberg, Florian; Rich, Stephen S.; Sholinsky, Phyliss; Arnett, Donna K.; Province, Michael E.; Myers, Richard H.; Eckfeldt, John H.; Williams, Roger R.; Hunt, Steven.

In: American Journal of Hypertension, Vol. 13, No. 3, 03.2000, p. 240-250.

Research output: Contribution to journalArticle

Kronenberg, F, Rich, SS, Sholinsky, P, Arnett, DK, Province, ME, Myers, RH, Eckfeldt, JH, Williams, RR & Hunt, S 2000, 'Insulin and hypertension in the NHLBI family heart study', American Journal of Hypertension, vol. 13, no. 3, pp. 240-250. https://doi.org/10.1016/S0895-7061(99)00177-6
Kronenberg F, Rich SS, Sholinsky P, Arnett DK, Province ME, Myers RH et al. Insulin and hypertension in the NHLBI family heart study. American Journal of Hypertension. 2000 Mar;13(3):240-250. https://doi.org/10.1016/S0895-7061(99)00177-6
Kronenberg, Florian ; Rich, Stephen S. ; Sholinsky, Phyliss ; Arnett, Donna K. ; Province, Michael E. ; Myers, Richard H. ; Eckfeldt, John H. ; Williams, Roger R. ; Hunt, Steven. / Insulin and hypertension in the NHLBI family heart study. In: American Journal of Hypertension. 2000 ; Vol. 13, No. 3. pp. 240-250.
@article{5a9121d9fe8c41e7ba9273f3c131c992,
title = "Insulin and hypertension in the NHLBI family heart study",
abstract = "The association between insulin and hypertension remains equivocal. We therefore investigated insulin levels in 3037 normotensive and 1067 hypertensive subjects from the National Heart, Lung and Blood Institute (NHLBI) Family Heart Study (FHS) by two different approaches. First, we compared insulin levels between normotensive and 275 untreated hypertensive subjects. Insulin levels unadjusted as well as adjusted for age, sex, and center were significantly higher in hypertensives. After adjustment for body mass index (BMI), insulin remained significantly higher only in the diastolic hypertensive group (mean ± SD 77.0 ± 36.7 pmol/L, P < .01) but not in the isolated systolic hypertensive group (67.0 ± 38.2 pmol/L) when compared to normotensives (63.2 ± 29.1 pmol/L). A sibpair analysis was then used that compared the intra-sibpair differences in insulin concentrations to the intra-sibpair differences in blood pressure (BP) levels. This approach was intended to control for the effects of genetic and residual shared environmental variance upon insulin levels. The intra-sibpair difference in insulin concentrations between concordant (diastolic and systolic ΔBP < 5 mm Hg) and discordant sibpairs (diastolic and systolic ΔBP > 15 and > 20 mm Hg, respectively) was no longer significantly different when adjusted for BMI (2.7 v 5.9 pmol/L for diastolic and -1.7 v -1.8 pmol/L for systolic BP). Even the random selection of one sibpair from each of the 326 families independently of insulin and BP levels did not result in a significant correlation between the intra-sibpair differences in insulin and BP. Using an insulin resistance index instead of insulin did not change our findings. Our investigation in the FHS sample of families suggests that there is only a small, if any, influence of insulin levels on BP after adjustment for obesity-related sources of variation. (C) 2000 American Journal of Hypertension, Ltd.",
keywords = "Body mass index, Hypertension, Insulin, Obesity, Sibpair study",
author = "Florian Kronenberg and Rich, {Stephen S.} and Phyliss Sholinsky and Arnett, {Donna K.} and Province, {Michael E.} and Myers, {Richard H.} and Eckfeldt, {John H.} and Williams, {Roger R.} and Steven Hunt",
year = "2000",
month = "3",
doi = "10.1016/S0895-7061(99)00177-6",
language = "English",
volume = "13",
pages = "240--250",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Insulin and hypertension in the NHLBI family heart study

AU - Kronenberg, Florian

AU - Rich, Stephen S.

AU - Sholinsky, Phyliss

AU - Arnett, Donna K.

AU - Province, Michael E.

AU - Myers, Richard H.

AU - Eckfeldt, John H.

AU - Williams, Roger R.

AU - Hunt, Steven

PY - 2000/3

Y1 - 2000/3

N2 - The association between insulin and hypertension remains equivocal. We therefore investigated insulin levels in 3037 normotensive and 1067 hypertensive subjects from the National Heart, Lung and Blood Institute (NHLBI) Family Heart Study (FHS) by two different approaches. First, we compared insulin levels between normotensive and 275 untreated hypertensive subjects. Insulin levels unadjusted as well as adjusted for age, sex, and center were significantly higher in hypertensives. After adjustment for body mass index (BMI), insulin remained significantly higher only in the diastolic hypertensive group (mean ± SD 77.0 ± 36.7 pmol/L, P < .01) but not in the isolated systolic hypertensive group (67.0 ± 38.2 pmol/L) when compared to normotensives (63.2 ± 29.1 pmol/L). A sibpair analysis was then used that compared the intra-sibpair differences in insulin concentrations to the intra-sibpair differences in blood pressure (BP) levels. This approach was intended to control for the effects of genetic and residual shared environmental variance upon insulin levels. The intra-sibpair difference in insulin concentrations between concordant (diastolic and systolic ΔBP < 5 mm Hg) and discordant sibpairs (diastolic and systolic ΔBP > 15 and > 20 mm Hg, respectively) was no longer significantly different when adjusted for BMI (2.7 v 5.9 pmol/L for diastolic and -1.7 v -1.8 pmol/L for systolic BP). Even the random selection of one sibpair from each of the 326 families independently of insulin and BP levels did not result in a significant correlation between the intra-sibpair differences in insulin and BP. Using an insulin resistance index instead of insulin did not change our findings. Our investigation in the FHS sample of families suggests that there is only a small, if any, influence of insulin levels on BP after adjustment for obesity-related sources of variation. (C) 2000 American Journal of Hypertension, Ltd.

AB - The association between insulin and hypertension remains equivocal. We therefore investigated insulin levels in 3037 normotensive and 1067 hypertensive subjects from the National Heart, Lung and Blood Institute (NHLBI) Family Heart Study (FHS) by two different approaches. First, we compared insulin levels between normotensive and 275 untreated hypertensive subjects. Insulin levels unadjusted as well as adjusted for age, sex, and center were significantly higher in hypertensives. After adjustment for body mass index (BMI), insulin remained significantly higher only in the diastolic hypertensive group (mean ± SD 77.0 ± 36.7 pmol/L, P < .01) but not in the isolated systolic hypertensive group (67.0 ± 38.2 pmol/L) when compared to normotensives (63.2 ± 29.1 pmol/L). A sibpair analysis was then used that compared the intra-sibpair differences in insulin concentrations to the intra-sibpair differences in blood pressure (BP) levels. This approach was intended to control for the effects of genetic and residual shared environmental variance upon insulin levels. The intra-sibpair difference in insulin concentrations between concordant (diastolic and systolic ΔBP < 5 mm Hg) and discordant sibpairs (diastolic and systolic ΔBP > 15 and > 20 mm Hg, respectively) was no longer significantly different when adjusted for BMI (2.7 v 5.9 pmol/L for diastolic and -1.7 v -1.8 pmol/L for systolic BP). Even the random selection of one sibpair from each of the 326 families independently of insulin and BP levels did not result in a significant correlation between the intra-sibpair differences in insulin and BP. Using an insulin resistance index instead of insulin did not change our findings. Our investigation in the FHS sample of families suggests that there is only a small, if any, influence of insulin levels on BP after adjustment for obesity-related sources of variation. (C) 2000 American Journal of Hypertension, Ltd.

KW - Body mass index

KW - Hypertension

KW - Insulin

KW - Obesity

KW - Sibpair study

UR - http://www.scopus.com/inward/record.url?scp=0034035846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034035846&partnerID=8YFLogxK

U2 - 10.1016/S0895-7061(99)00177-6

DO - 10.1016/S0895-7061(99)00177-6

M3 - Article

VL - 13

SP - 240

EP - 250

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 3

ER -