Inhibitory activity of cyclosporine is dependent on the activating signal(s) provided to T cells

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of cyclosporine on T cell activation induced by monoclonal anti-CD3 antibodies, 12-O-tetradecanoyl phorbol-13-myristate acetate (TPA), or human recombinant interleukin 2 (IL-2) were investigated. Cyclosporine inhibited anti-CD3-mediated expression of IL-2 receptors and IL-2 factor production by peripheral blood mononuclear cells (PBM). Cyclosporine did not inhibit when TPA rather than anti-CD3 was used to activate the PBM. Effects of cyclosporine on the activation of memory T cells were also dependent on the stimulus used to activate memory T cells. Cyclosporine inhibited alloantigen associated memory T cell activation, but not when IL-2 provided the necessary triggering signal to memory T cells. IL-2-mediated memory T cell activation was inhibitable with monoclonal antibodies directed at the IL-2 receptor or at the IL-2 factor. Collectively, these findings indicate that the inhibitory activity of cyclosporine is dependent on the activating signals provided to T cells. Moreover, antibodies directed at the IL-2 system together with cyclosporine might prove to be more potent immunosuppressants than either agent alone.

Original languageEnglish
Pages (from-to)1008-1011
Number of pages4
JournalThe Journal of Pediatrics
Volume111
Issue number6 PART 2
DOIs
Publication statusPublished - 1 Jan 1987
Externally publishedYes

Fingerprint

Cyclosporine
Interleukin-2
T-Lymphocytes
Interleukin-2 Receptors
Tetradecanoylphorbol Acetate
Blood Cells
Monoclonal Antibodies
Isoantigens
Immunosuppressive Agents
Anti-Idiotypic Antibodies
Antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Inhibitory activity of cyclosporine is dependent on the activating signal(s) provided to T cells. / Suthanthiran, Manikkam.

In: The Journal of Pediatrics, Vol. 111, No. 6 PART 2, 01.01.1987, p. 1008-1011.

Research output: Contribution to journalArticle

@article{961ae4e9c003485a88b3a94ad4f5c416,
title = "Inhibitory activity of cyclosporine is dependent on the activating signal(s) provided to T cells",
abstract = "The effects of cyclosporine on T cell activation induced by monoclonal anti-CD3 antibodies, 12-O-tetradecanoyl phorbol-13-myristate acetate (TPA), or human recombinant interleukin 2 (IL-2) were investigated. Cyclosporine inhibited anti-CD3-mediated expression of IL-2 receptors and IL-2 factor production by peripheral blood mononuclear cells (PBM). Cyclosporine did not inhibit when TPA rather than anti-CD3 was used to activate the PBM. Effects of cyclosporine on the activation of memory T cells were also dependent on the stimulus used to activate memory T cells. Cyclosporine inhibited alloantigen associated memory T cell activation, but not when IL-2 provided the necessary triggering signal to memory T cells. IL-2-mediated memory T cell activation was inhibitable with monoclonal antibodies directed at the IL-2 receptor or at the IL-2 factor. Collectively, these findings indicate that the inhibitory activity of cyclosporine is dependent on the activating signals provided to T cells. Moreover, antibodies directed at the IL-2 system together with cyclosporine might prove to be more potent immunosuppressants than either agent alone.",
author = "Manikkam Suthanthiran",
year = "1987",
month = "1",
day = "1",
doi = "10.1016/S0022-3476(87)80046-X",
language = "English",
volume = "111",
pages = "1008--1011",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "6 PART 2",

}

TY - JOUR

T1 - Inhibitory activity of cyclosporine is dependent on the activating signal(s) provided to T cells

AU - Suthanthiran, Manikkam

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The effects of cyclosporine on T cell activation induced by monoclonal anti-CD3 antibodies, 12-O-tetradecanoyl phorbol-13-myristate acetate (TPA), or human recombinant interleukin 2 (IL-2) were investigated. Cyclosporine inhibited anti-CD3-mediated expression of IL-2 receptors and IL-2 factor production by peripheral blood mononuclear cells (PBM). Cyclosporine did not inhibit when TPA rather than anti-CD3 was used to activate the PBM. Effects of cyclosporine on the activation of memory T cells were also dependent on the stimulus used to activate memory T cells. Cyclosporine inhibited alloantigen associated memory T cell activation, but not when IL-2 provided the necessary triggering signal to memory T cells. IL-2-mediated memory T cell activation was inhibitable with monoclonal antibodies directed at the IL-2 receptor or at the IL-2 factor. Collectively, these findings indicate that the inhibitory activity of cyclosporine is dependent on the activating signals provided to T cells. Moreover, antibodies directed at the IL-2 system together with cyclosporine might prove to be more potent immunosuppressants than either agent alone.

AB - The effects of cyclosporine on T cell activation induced by monoclonal anti-CD3 antibodies, 12-O-tetradecanoyl phorbol-13-myristate acetate (TPA), or human recombinant interleukin 2 (IL-2) were investigated. Cyclosporine inhibited anti-CD3-mediated expression of IL-2 receptors and IL-2 factor production by peripheral blood mononuclear cells (PBM). Cyclosporine did not inhibit when TPA rather than anti-CD3 was used to activate the PBM. Effects of cyclosporine on the activation of memory T cells were also dependent on the stimulus used to activate memory T cells. Cyclosporine inhibited alloantigen associated memory T cell activation, but not when IL-2 provided the necessary triggering signal to memory T cells. IL-2-mediated memory T cell activation was inhibitable with monoclonal antibodies directed at the IL-2 receptor or at the IL-2 factor. Collectively, these findings indicate that the inhibitory activity of cyclosporine is dependent on the activating signals provided to T cells. Moreover, antibodies directed at the IL-2 system together with cyclosporine might prove to be more potent immunosuppressants than either agent alone.

UR - http://www.scopus.com/inward/record.url?scp=0023598481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023598481&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(87)80046-X

DO - 10.1016/S0022-3476(87)80046-X

M3 - Article

VL - 111

SP - 1008

EP - 1011

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 6 PART 2

ER -