Inhibition of HIV-1 replication in human lymphoid tissues ex vivo by measles virus

Jean-Charles B. Grivel, Mayra Garcia, William J. Moss, Leonid B. Margolis

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) type 1 replication and disease progression are enhanced by various pathogens in coinfected individuals. However, acute infection with measles virus (MV) has been found to suppress HIV-1 replication in coinfected children. We investigated the mechanisms of this phenomenon using human lymphoid tissues coinfected ex vivo with HIV-1 and MV. MV inhibited both CXCR4-tropic (X4) and CCR5-tropic (R5) HIV-1, but the inhibitory effect was particularly profound for R5 virus, which transmits infection and dominates the early stages of HIV-1 disease. MV inhibits the replication of R5 HIV-1 in coinfected tissues by up-regulation of the CC chemokine RANTES, a well-known inhibitor of R5 HIV-1 infection, and this up-regulation is augmented in tissues coinfected with R5 HIV-1. Deciphering the molecular mechanisms by which MV and other pathogens alter local cytokine/chemokine networks and cause tissue microenvironments to become detrimental to HIV-1 may significantly contribute to the development of effective anti-HIV therapies.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalJournal of Infectious Diseases
Volume192
Issue number1
DOIs
Publication statusPublished - 1 Jul 2005
Externally publishedYes

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Measles virus
Lymphoid Tissue
Virus Replication
HIV-1
Virus Diseases
Up-Regulation
Chemokine CCL5
CC Chemokines
Infection
Chemokines
Disease Progression
HIV
Cytokines
Viruses

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Inhibition of HIV-1 replication in human lymphoid tissues ex vivo by measles virus. / Grivel, Jean-Charles B.; Garcia, Mayra; Moss, William J.; Margolis, Leonid B.

In: Journal of Infectious Diseases, Vol. 192, No. 1, 01.07.2005, p. 71-78.

Research output: Contribution to journalArticle

Grivel, Jean-Charles B. ; Garcia, Mayra ; Moss, William J. ; Margolis, Leonid B. / Inhibition of HIV-1 replication in human lymphoid tissues ex vivo by measles virus. In: Journal of Infectious Diseases. 2005 ; Vol. 192, No. 1. pp. 71-78.
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