Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis

Sayaka Mito, Rajarajan A. Thandavarayan, Meilei Ma, Arun Lakshmanan, Kenji Suzuki, Makoto Kodama, Kenichi Watanabe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Curcumin is used anecdotally as an herb in traditional Indian and Chinese medicine. In the present study, the effects and possible mechanism of curcumin in experimental autoimmune myocarditis (EAM) rats were further investigated. They were divided randomly into a treatment and vehicle group, and orally administrated curcumin (50 mg/kg/day) and 1% gum arabic, respectively, for 3 weeks after myosin injection. The results showed that curcumin significantly suppressed the myocardial protein expression of inducible nitric oxide synthase (iNOS) and the catalytic subunit of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase. In addition, curcumin significantly decreased myocardial endoplasmic reticulum (ER) stress signaling proteins and improved cardiac function. Furthermore, curcumin significantly decreased the key regulators or inducers of apoptosis. In summary, our results indicate that curcumin has the potential to protect EAM by modulating cardiac oxidative and ER stress-mediated apoptosis, and provides a novel therapeutic strategy for autoimmune myocarditis.

Original languageEnglish
Pages (from-to)1223-1231
Number of pages9
JournalFree Radical Research
Volume45
Issue number10
DOIs
Publication statusPublished - 1 Oct 2011
Externally publishedYes

Fingerprint

Endoplasmic Reticulum Stress
Curcumin
Myocarditis
Apoptosis
Therapeutics
Gum Arabic
Chinese Traditional Medicine
Nitric Oxide Synthase Type II
Myosins
Heat-Shock Proteins
NADP
Medicine
Rats
Catalytic Domain
Oxidoreductases
Proteins
Injections

Keywords

  • Apoptosis
  • Autoimmune myocarditis
  • Curcumin
  • Endoplasmic reticulum stress
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry

Cite this

Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis. / Mito, Sayaka; Thandavarayan, Rajarajan A.; Ma, Meilei; Lakshmanan, Arun; Suzuki, Kenji; Kodama, Makoto; Watanabe, Kenichi.

In: Free Radical Research, Vol. 45, No. 10, 01.10.2011, p. 1223-1231.

Research output: Contribution to journalArticle

Mito, Sayaka ; Thandavarayan, Rajarajan A. ; Ma, Meilei ; Lakshmanan, Arun ; Suzuki, Kenji ; Kodama, Makoto ; Watanabe, Kenichi. / Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis. In: Free Radical Research. 2011 ; Vol. 45, No. 10. pp. 1223-1231.
@article{0337a8aa82e146f0a08dfcd6309c61cb,
title = "Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis",
abstract = "Curcumin is used anecdotally as an herb in traditional Indian and Chinese medicine. In the present study, the effects and possible mechanism of curcumin in experimental autoimmune myocarditis (EAM) rats were further investigated. They were divided randomly into a treatment and vehicle group, and orally administrated curcumin (50 mg/kg/day) and 1{\%} gum arabic, respectively, for 3 weeks after myosin injection. The results showed that curcumin significantly suppressed the myocardial protein expression of inducible nitric oxide synthase (iNOS) and the catalytic subunit of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase. In addition, curcumin significantly decreased myocardial endoplasmic reticulum (ER) stress signaling proteins and improved cardiac function. Furthermore, curcumin significantly decreased the key regulators or inducers of apoptosis. In summary, our results indicate that curcumin has the potential to protect EAM by modulating cardiac oxidative and ER stress-mediated apoptosis, and provides a novel therapeutic strategy for autoimmune myocarditis.",
keywords = "Apoptosis, Autoimmune myocarditis, Curcumin, Endoplasmic reticulum stress, Oxidative stress",
author = "Sayaka Mito and Thandavarayan, {Rajarajan A.} and Meilei Ma and Arun Lakshmanan and Kenji Suzuki and Makoto Kodama and Kenichi Watanabe",
year = "2011",
month = "10",
day = "1",
doi = "10.3109/10715762.2011.607252",
language = "English",
volume = "45",
pages = "1223--1231",
journal = "Free Radical Research",
issn = "1071-5762",
publisher = "Informa Healthcare",
number = "10",

}

TY - JOUR

T1 - Inhibition of cardiac oxidative and endoplasmic reticulum stress-mediated apoptosis by curcumin treatment contributes to protection against acute myocarditis

AU - Mito, Sayaka

AU - Thandavarayan, Rajarajan A.

AU - Ma, Meilei

AU - Lakshmanan, Arun

AU - Suzuki, Kenji

AU - Kodama, Makoto

AU - Watanabe, Kenichi

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Curcumin is used anecdotally as an herb in traditional Indian and Chinese medicine. In the present study, the effects and possible mechanism of curcumin in experimental autoimmune myocarditis (EAM) rats were further investigated. They were divided randomly into a treatment and vehicle group, and orally administrated curcumin (50 mg/kg/day) and 1% gum arabic, respectively, for 3 weeks after myosin injection. The results showed that curcumin significantly suppressed the myocardial protein expression of inducible nitric oxide synthase (iNOS) and the catalytic subunit of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase. In addition, curcumin significantly decreased myocardial endoplasmic reticulum (ER) stress signaling proteins and improved cardiac function. Furthermore, curcumin significantly decreased the key regulators or inducers of apoptosis. In summary, our results indicate that curcumin has the potential to protect EAM by modulating cardiac oxidative and ER stress-mediated apoptosis, and provides a novel therapeutic strategy for autoimmune myocarditis.

AB - Curcumin is used anecdotally as an herb in traditional Indian and Chinese medicine. In the present study, the effects and possible mechanism of curcumin in experimental autoimmune myocarditis (EAM) rats were further investigated. They were divided randomly into a treatment and vehicle group, and orally administrated curcumin (50 mg/kg/day) and 1% gum arabic, respectively, for 3 weeks after myosin injection. The results showed that curcumin significantly suppressed the myocardial protein expression of inducible nitric oxide synthase (iNOS) and the catalytic subunit of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase. In addition, curcumin significantly decreased myocardial endoplasmic reticulum (ER) stress signaling proteins and improved cardiac function. Furthermore, curcumin significantly decreased the key regulators or inducers of apoptosis. In summary, our results indicate that curcumin has the potential to protect EAM by modulating cardiac oxidative and ER stress-mediated apoptosis, and provides a novel therapeutic strategy for autoimmune myocarditis.

KW - Apoptosis

KW - Autoimmune myocarditis

KW - Curcumin

KW - Endoplasmic reticulum stress

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=80052703488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052703488&partnerID=8YFLogxK

U2 - 10.3109/10715762.2011.607252

DO - 10.3109/10715762.2011.607252

M3 - Article

VL - 45

SP - 1223

EP - 1231

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 10

ER -