Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

Carmelo Luci, Ana Reynders, Ivaylo I. Ivanov, Celine Cognet, Laurent Chiche, Lionel Chasson, Jean Hardwigsen, Esperanza Anguiano, Jacques Banchereau, Damien J. Chaussabel, Marc Dalod, Dan R. Littman, Eric Vivier, Elena Tomasello

Research output: Contribution to journalArticle

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Abstract

NKp46+CD3- natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-γ. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46+CD3- cells with a diminished capacity to degranulate and produce interferon-γ. In the gut, expression of the transcription factor RORγt, which is involved in the development of lymphoid tissue-inducer cells, defined a previously unknown subset of NKp46+CD3- lymphocytes. Unlike RORγt- lamina propria and dermis natural killer cells, gut RORγt+NKp46+ cells produced interleukin 22. Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalNature Immunology
Volume10
Issue number1
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Transcription Factors
Lymphoid Tissue
Dermis
Helper-Inducer T-Lymphocytes
Natural Killer Cells
Skin
Interferons
Mucous Membrane
Lymphocytes
Population
Innate Immunity
Uterus
Lung
Liver
interleukin-22

ASJC Scopus subject areas

  • Immunology

Cite this

Luci, C., Reynders, A., Ivanov, I. I., Cognet, C., Chiche, L., Chasson, L., ... Tomasello, E. (2009). Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin. Nature Immunology, 10(1), 75-82. https://doi.org/10.1038/ni.1681

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin. / Luci, Carmelo; Reynders, Ana; Ivanov, Ivaylo I.; Cognet, Celine; Chiche, Laurent; Chasson, Lionel; Hardwigsen, Jean; Anguiano, Esperanza; Banchereau, Jacques; Chaussabel, Damien J.; Dalod, Marc; Littman, Dan R.; Vivier, Eric; Tomasello, Elena.

In: Nature Immunology, Vol. 10, No. 1, 2009, p. 75-82.

Research output: Contribution to journalArticle

Luci, C, Reynders, A, Ivanov, II, Cognet, C, Chiche, L, Chasson, L, Hardwigsen, J, Anguiano, E, Banchereau, J, Chaussabel, DJ, Dalod, M, Littman, DR, Vivier, E & Tomasello, E 2009, 'Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin', Nature Immunology, vol. 10, no. 1, pp. 75-82. https://doi.org/10.1038/ni.1681
Luci, Carmelo ; Reynders, Ana ; Ivanov, Ivaylo I. ; Cognet, Celine ; Chiche, Laurent ; Chasson, Lionel ; Hardwigsen, Jean ; Anguiano, Esperanza ; Banchereau, Jacques ; Chaussabel, Damien J. ; Dalod, Marc ; Littman, Dan R. ; Vivier, Eric ; Tomasello, Elena. / Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin. In: Nature Immunology. 2009 ; Vol. 10, No. 1. pp. 75-82.
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