Influence of sodium intake on the reliability of active renin as a measure of the renin-angiotensin system in essential hypertension

S. Hurwitz, B. Potter, R. J. Weiss, X. Jeunemaitre, P. N. Hopkins, Steven Hunt, W. R. Litchfield, G. H. Williams

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Plasma renin activity (PRA), active renin (AR), prorenin, and angiotensinogen were assessed in 486 hypertensive and 175 normotensive subjects with a sodium intake of 10 or 200 mEq/d during supine and upright posture and after infusion of angiotensin II. PRA and AR levels were compared in hypertensive subjects in each condition. With low sodium intake, particularly while upright, there was a significant correlation between PRA and AR. In upright subjects with low sodium intake who had a PRA of 2.4 ng/mL per hour or less (1.85 nmol · L-1 · h-1 or less), the correlation was also strong. With high sodium intake, the correlation was weaker. With intermediate sodium excretion, the correlation was intermediate. Prorenin was less predictive of PRA than was AR, and angiotensinogen had a marginal role. Using PRA during sodium restriction while upright as the standard for determining renin status, the precision of AR for predicting renin status was excellent. AR may be used for surrogate assessment of the renin-angiotensin system activity when the system is activated.

Original languageEnglish
Pages (from-to)304-312
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume115
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Renin-Angiotensin System
Renin
Sodium
Angiotensinogen
Essential Hypertension
Posture
Angiotensin II

Keywords

  • Active renin
  • Essential hypertension
  • Plasma renin activity
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Influence of sodium intake on the reliability of active renin as a measure of the renin-angiotensin system in essential hypertension. / Hurwitz, S.; Potter, B.; Weiss, R. J.; Jeunemaitre, X.; Hopkins, P. N.; Hunt, Steven; Litchfield, W. R.; Williams, G. H.

In: American Journal of Clinical Pathology, Vol. 115, No. 2, 2001, p. 304-312.

Research output: Contribution to journalArticle

Hurwitz, S. ; Potter, B. ; Weiss, R. J. ; Jeunemaitre, X. ; Hopkins, P. N. ; Hunt, Steven ; Litchfield, W. R. ; Williams, G. H. / Influence of sodium intake on the reliability of active renin as a measure of the renin-angiotensin system in essential hypertension. In: American Journal of Clinical Pathology. 2001 ; Vol. 115, No. 2. pp. 304-312.
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AU - Hopkins, P. N.

AU - Hunt, Steven

AU - Litchfield, W. R.

AU - Williams, G. H.

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