Influence of Nω-nitro-L-arginine methyl on pressor responses elicited by sympathetic nerve stimulation in pithed normotensive and hypertensive rats

Reza Tabrizchi, Christopher Triggle

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18 Citations (Scopus)

Abstract

The effects of Nω-nitro-L-arginine methyl ester (L-NAME) were examined on pressor responses elicited by sympathetic nerve stimulation (SNS) in the pithed spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Frequency-response curves (1-20 Hz) were carried out by using the pithing rod to stimulate the sympathetic chain. SNS produced an increase in the blood pressure of the pithed rats which was dependent on the frequency of the applied stimuli, however, a significantly greater increase was observed for the blood pressure of SH versus WKY rats. Bolus i.v. injections of L-NAME (0.03-1.0 mg/kg) augmented the increase in the blood pressure resulting from SNS. The potentiating effects of L-NAME displayed frequency as well as dose-dependency and the augmentation produced following the administration of L-NAME was greater in magnitude in the SH as compared to WKY rats. These differential effects of L-NAME in SH versus WKY rats suggest that the levels of L-arginine-derived nitric oxide are higher in the SH rats. Such an increase may reflect a compensatory response resulting from the elevated blood pressure of the SH rats.

Original languageEnglish
Pages (from-to)1989-1995
Number of pages7
JournalLife Sciences
Volume49
Issue number26
DOIs
Publication statusPublished - 1991
Externally publishedYes

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NG-Nitroarginine Methyl Ester
Inbred WKY Rats
Arginine
Rats
Blood pressure
Blood Pressure
Inbred SHR Rats
Nitric Oxide
Frequency response
Injections
Esters

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Influence of Nω-nitro-L-arginine methyl on pressor responses elicited by sympathetic nerve stimulation in pithed normotensive and hypertensive rats",
abstract = "The effects of Nω-nitro-L-arginine methyl ester (L-NAME) were examined on pressor responses elicited by sympathetic nerve stimulation (SNS) in the pithed spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Frequency-response curves (1-20 Hz) were carried out by using the pithing rod to stimulate the sympathetic chain. SNS produced an increase in the blood pressure of the pithed rats which was dependent on the frequency of the applied stimuli, however, a significantly greater increase was observed for the blood pressure of SH versus WKY rats. Bolus i.v. injections of L-NAME (0.03-1.0 mg/kg) augmented the increase in the blood pressure resulting from SNS. The potentiating effects of L-NAME displayed frequency as well as dose-dependency and the augmentation produced following the administration of L-NAME was greater in magnitude in the SH as compared to WKY rats. These differential effects of L-NAME in SH versus WKY rats suggest that the levels of L-arginine-derived nitric oxide are higher in the SH rats. Such an increase may reflect a compensatory response resulting from the elevated blood pressure of the SH rats.",
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AU - Triggle, Christopher

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N2 - The effects of Nω-nitro-L-arginine methyl ester (L-NAME) were examined on pressor responses elicited by sympathetic nerve stimulation (SNS) in the pithed spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Frequency-response curves (1-20 Hz) were carried out by using the pithing rod to stimulate the sympathetic chain. SNS produced an increase in the blood pressure of the pithed rats which was dependent on the frequency of the applied stimuli, however, a significantly greater increase was observed for the blood pressure of SH versus WKY rats. Bolus i.v. injections of L-NAME (0.03-1.0 mg/kg) augmented the increase in the blood pressure resulting from SNS. The potentiating effects of L-NAME displayed frequency as well as dose-dependency and the augmentation produced following the administration of L-NAME was greater in magnitude in the SH as compared to WKY rats. These differential effects of L-NAME in SH versus WKY rats suggest that the levels of L-arginine-derived nitric oxide are higher in the SH rats. Such an increase may reflect a compensatory response resulting from the elevated blood pressure of the SH rats.

AB - The effects of Nω-nitro-L-arginine methyl ester (L-NAME) were examined on pressor responses elicited by sympathetic nerve stimulation (SNS) in the pithed spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Frequency-response curves (1-20 Hz) were carried out by using the pithing rod to stimulate the sympathetic chain. SNS produced an increase in the blood pressure of the pithed rats which was dependent on the frequency of the applied stimuli, however, a significantly greater increase was observed for the blood pressure of SH versus WKY rats. Bolus i.v. injections of L-NAME (0.03-1.0 mg/kg) augmented the increase in the blood pressure resulting from SNS. The potentiating effects of L-NAME displayed frequency as well as dose-dependency and the augmentation produced following the administration of L-NAME was greater in magnitude in the SH as compared to WKY rats. These differential effects of L-NAME in SH versus WKY rats suggest that the levels of L-arginine-derived nitric oxide are higher in the SH rats. Such an increase may reflect a compensatory response resulting from the elevated blood pressure of the SH rats.

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