Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women

Antonio Nouvenne, Andrea Ticinesi, Angela Guerra, Giuseppina Folesani, Franca Allegri, Silvana Pinelli, Paolo Baroni, Mario Pedrazzoni, Giuseppe Lippi, Annalisa Terranegra, Elena Dogliotti, Laura Soldati, Loris Borghi, Tiziana Meschi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bone mineral density (BMD) in a cohort of healthy females.Materials and methods: 78 female volunteers (mean age 46 ± 6 years) were enrolled at the Stone Clinic of Parma University Hospital and subdued to 24-hour urine collection for lithogenic risk profile, DEXA, and 3-day dietary diary. We defined two mathematical indexes derived from body composition measurement (index of lean mass-ILM, and index of fat mass-IFM) and the cohort was split using the median value of each index, obtaining groups differing only for lean or fat mass. We then analyzed differences in urine composition, dietary intakes and BMD. Results: The women with high values of ILM had significantly higher excretion of creatinine (991 ± 194 vs 1138 ± 191 mg/day, p = 0.001), potassium (47 ± 13 vs 60 ± 18 mEq/day, p < 0.001), phosphorus (520 ± 174 vs 665 ± 186 mg/day, p < 0.001), magnesium (66 ± 20 vs 85 ± 26 mg/day, p < 0.001), citrate (620 ± 178 vs 807 ± 323 mg/day, p = 0.002) and oxalate (21 ± 7 vs 27 ± 11 mg/day, p = 0.015) and a significantly better BMD values in limbs than other women with low values of ILM. The women with high values of IFM had similar urine composition to other women with low values of IFM, but significantly better BMD in axial sites. No differences in dietary habits were found in both analyses. Conclusions: Lean mass seems to significantly influence urine composition both in terms of lithogenesis promoters and inhibitors, while fat mass does not. Lean mass influences bone quality only in limb skeleton, while fat mass influences bone quality only in axial sites.

Original languageEnglish
Article number248
JournalJournal of Translational Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - 7 Oct 2013
Externally publishedYes

Fingerprint

Urinary Calculi
Bone Density
Minerals
Bone
Fats
Urine
Chemical analysis
Body Composition
Bone and Bones
Extremities
Urine Specimen Collection
Oxalates
Feeding Behavior
Skeleton
Citric Acid
Phosphorus
Magnesium
Volunteers
Creatinine
Potassium

Keywords

  • Body composition
  • Bone mineral density
  • Fat mass
  • Lean mass
  • Urinary lithogenic risk factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Nouvenne, A., Ticinesi, A., Guerra, A., Folesani, G., Allegri, F., Pinelli, S., ... Meschi, T. (2013). Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women. Journal of Translational Medicine, 11(1), [248]. https://doi.org/10.1186/1479-5876-11-248

Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women. / Nouvenne, Antonio; Ticinesi, Andrea; Guerra, Angela; Folesani, Giuseppina; Allegri, Franca; Pinelli, Silvana; Baroni, Paolo; Pedrazzoni, Mario; Lippi, Giuseppe; Terranegra, Annalisa; Dogliotti, Elena; Soldati, Laura; Borghi, Loris; Meschi, Tiziana.

In: Journal of Translational Medicine, Vol. 11, No. 1, 248, 07.10.2013.

Research output: Contribution to journalArticle

Nouvenne, A, Ticinesi, A, Guerra, A, Folesani, G, Allegri, F, Pinelli, S, Baroni, P, Pedrazzoni, M, Lippi, G, Terranegra, A, Dogliotti, E, Soldati, L, Borghi, L & Meschi, T 2013, 'Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women', Journal of Translational Medicine, vol. 11, no. 1, 248. https://doi.org/10.1186/1479-5876-11-248
Nouvenne, Antonio ; Ticinesi, Andrea ; Guerra, Angela ; Folesani, Giuseppina ; Allegri, Franca ; Pinelli, Silvana ; Baroni, Paolo ; Pedrazzoni, Mario ; Lippi, Giuseppe ; Terranegra, Annalisa ; Dogliotti, Elena ; Soldati, Laura ; Borghi, Loris ; Meschi, Tiziana. / Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women. In: Journal of Translational Medicine. 2013 ; Vol. 11, No. 1.
@article{6e46a12704ee49fa8aad3331272e8707,
title = "Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women",
abstract = "Background: The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bone mineral density (BMD) in a cohort of healthy females.Materials and methods: 78 female volunteers (mean age 46 ± 6 years) were enrolled at the Stone Clinic of Parma University Hospital and subdued to 24-hour urine collection for lithogenic risk profile, DEXA, and 3-day dietary diary. We defined two mathematical indexes derived from body composition measurement (index of lean mass-ILM, and index of fat mass-IFM) and the cohort was split using the median value of each index, obtaining groups differing only for lean or fat mass. We then analyzed differences in urine composition, dietary intakes and BMD. Results: The women with high values of ILM had significantly higher excretion of creatinine (991 ± 194 vs 1138 ± 191 mg/day, p = 0.001), potassium (47 ± 13 vs 60 ± 18 mEq/day, p < 0.001), phosphorus (520 ± 174 vs 665 ± 186 mg/day, p < 0.001), magnesium (66 ± 20 vs 85 ± 26 mg/day, p < 0.001), citrate (620 ± 178 vs 807 ± 323 mg/day, p = 0.002) and oxalate (21 ± 7 vs 27 ± 11 mg/day, p = 0.015) and a significantly better BMD values in limbs than other women with low values of ILM. The women with high values of IFM had similar urine composition to other women with low values of IFM, but significantly better BMD in axial sites. No differences in dietary habits were found in both analyses. Conclusions: Lean mass seems to significantly influence urine composition both in terms of lithogenesis promoters and inhibitors, while fat mass does not. Lean mass influences bone quality only in limb skeleton, while fat mass influences bone quality only in axial sites.",
keywords = "Body composition, Bone mineral density, Fat mass, Lean mass, Urinary lithogenic risk factors",
author = "Antonio Nouvenne and Andrea Ticinesi and Angela Guerra and Giuseppina Folesani and Franca Allegri and Silvana Pinelli and Paolo Baroni and Mario Pedrazzoni and Giuseppe Lippi and Annalisa Terranegra and Elena Dogliotti and Laura Soldati and Loris Borghi and Tiziana Meschi",
year = "2013",
month = "10",
day = "7",
doi = "10.1186/1479-5876-11-248",
language = "English",
volume = "11",
journal = "Journal of Translational Medicine",
issn = "1479-5876",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women

AU - Nouvenne, Antonio

AU - Ticinesi, Andrea

AU - Guerra, Angela

AU - Folesani, Giuseppina

AU - Allegri, Franca

AU - Pinelli, Silvana

AU - Baroni, Paolo

AU - Pedrazzoni, Mario

AU - Lippi, Giuseppe

AU - Terranegra, Annalisa

AU - Dogliotti, Elena

AU - Soldati, Laura

AU - Borghi, Loris

AU - Meschi, Tiziana

PY - 2013/10/7

Y1 - 2013/10/7

N2 - Background: The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bone mineral density (BMD) in a cohort of healthy females.Materials and methods: 78 female volunteers (mean age 46 ± 6 years) were enrolled at the Stone Clinic of Parma University Hospital and subdued to 24-hour urine collection for lithogenic risk profile, DEXA, and 3-day dietary diary. We defined two mathematical indexes derived from body composition measurement (index of lean mass-ILM, and index of fat mass-IFM) and the cohort was split using the median value of each index, obtaining groups differing only for lean or fat mass. We then analyzed differences in urine composition, dietary intakes and BMD. Results: The women with high values of ILM had significantly higher excretion of creatinine (991 ± 194 vs 1138 ± 191 mg/day, p = 0.001), potassium (47 ± 13 vs 60 ± 18 mEq/day, p < 0.001), phosphorus (520 ± 174 vs 665 ± 186 mg/day, p < 0.001), magnesium (66 ± 20 vs 85 ± 26 mg/day, p < 0.001), citrate (620 ± 178 vs 807 ± 323 mg/day, p = 0.002) and oxalate (21 ± 7 vs 27 ± 11 mg/day, p = 0.015) and a significantly better BMD values in limbs than other women with low values of ILM. The women with high values of IFM had similar urine composition to other women with low values of IFM, but significantly better BMD in axial sites. No differences in dietary habits were found in both analyses. Conclusions: Lean mass seems to significantly influence urine composition both in terms of lithogenesis promoters and inhibitors, while fat mass does not. Lean mass influences bone quality only in limb skeleton, while fat mass influences bone quality only in axial sites.

AB - Background: The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bone mineral density (BMD) in a cohort of healthy females.Materials and methods: 78 female volunteers (mean age 46 ± 6 years) were enrolled at the Stone Clinic of Parma University Hospital and subdued to 24-hour urine collection for lithogenic risk profile, DEXA, and 3-day dietary diary. We defined two mathematical indexes derived from body composition measurement (index of lean mass-ILM, and index of fat mass-IFM) and the cohort was split using the median value of each index, obtaining groups differing only for lean or fat mass. We then analyzed differences in urine composition, dietary intakes and BMD. Results: The women with high values of ILM had significantly higher excretion of creatinine (991 ± 194 vs 1138 ± 191 mg/day, p = 0.001), potassium (47 ± 13 vs 60 ± 18 mEq/day, p < 0.001), phosphorus (520 ± 174 vs 665 ± 186 mg/day, p < 0.001), magnesium (66 ± 20 vs 85 ± 26 mg/day, p < 0.001), citrate (620 ± 178 vs 807 ± 323 mg/day, p = 0.002) and oxalate (21 ± 7 vs 27 ± 11 mg/day, p = 0.015) and a significantly better BMD values in limbs than other women with low values of ILM. The women with high values of IFM had similar urine composition to other women with low values of IFM, but significantly better BMD in axial sites. No differences in dietary habits were found in both analyses. Conclusions: Lean mass seems to significantly influence urine composition both in terms of lithogenesis promoters and inhibitors, while fat mass does not. Lean mass influences bone quality only in limb skeleton, while fat mass influences bone quality only in axial sites.

KW - Body composition

KW - Bone mineral density

KW - Fat mass

KW - Lean mass

KW - Urinary lithogenic risk factors

UR - http://www.scopus.com/inward/record.url?scp=84884996980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884996980&partnerID=8YFLogxK

U2 - 10.1186/1479-5876-11-248

DO - 10.1186/1479-5876-11-248

M3 - Article

C2 - 24099643

AN - SCOPUS:84884996980

VL - 11

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

SN - 1479-5876

IS - 1

M1 - 248

ER -