Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p,p′-DDT among preschoolers

Eva Morales, Jordi Sunyer, Francesc Castro-Giner, Xavier P. Estivill, Jordi Julvez, Nuria Ribas-Fitó, Maties Torrent, Joan O. Grimalt, Rafael de Cid

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Early-life exposure to p,p'-DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] is associated with a decrease in cognitive skills among preschoolers at 4 years of age. We hypothesized that genetic variability in glutathione S-transferase (GST) genes (GSTP1, GSTM1, and GSTT1) could influence the effects of prenatal exposure to p,p'-DDT. Methods: We used data from 326 children assessed in a prospective population-based birth cohort at the age of 4 years. In that study, the McCarthy Scales of Children's Abilities were administrated by psychologists, organochlorine compounds were measured in cord serum, and genotyping was conducted for the coding variant Ile105Val from GSTP1 and for null alleles from GSTM1 and GSTT1. We used linear regression models to measure the association between organochlorines and neurodevelopmental scores by GST polymorphisms. Results: p,p'-DDT cord serum concentration was inversely associated with general cognitive, memory, quantitative, and verbal skills, as well as executive function and working memory, in children who had any GSTP1 Val-105 allele. GSTP1 polymorphisms and prenatal p,p'-DDT exposure showed a statistically significant interaction for general cognitive skills (p = 0.05), quantitative skills (p = 0.02), executive function (p = 0.01), and working memory (p = 0.02). There were no significant associations between p,p'-DDT and cognitive functioning at 4 years of age according to GSTM1 and GSTT1 polymorphisms. Conclusions: Results indicate that children with GSTP1 Val-105 allele were at higher risk of the adverse cognitive functioning effects of prenatal p,p'-DDT exposure.

Original languageEnglish
Pages (from-to)1581-1585
Number of pages5
JournalEnvironmental Health Perspectives
Volume116
Issue number11
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

DDT
Glutathione Transferase
Alleles
Executive Function
Short-Term Memory
Linear Models
Chlorinated Hydrocarbons
Aptitude
Serum
Parturition
Psychology
Population
Genes

Keywords

  • Children
  • Cognitive functioning
  • Gene-environment interaction
  • Glutathione S-transferase
  • Neurodevelopment
  • p,p′-DDE
  • p,p′-DDT
  • Polymorphism

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p,p′-DDT among preschoolers. / Morales, Eva; Sunyer, Jordi; Castro-Giner, Francesc; Estivill, Xavier P.; Julvez, Jordi; Ribas-Fitó, Nuria; Torrent, Maties; Grimalt, Joan O.; de Cid, Rafael.

In: Environmental Health Perspectives, Vol. 116, No. 11, 2008, p. 1581-1585.

Research output: Contribution to journalArticle

Morales, E, Sunyer, J, Castro-Giner, F, Estivill, XP, Julvez, J, Ribas-Fitó, N, Torrent, M, Grimalt, JO & de Cid, R 2008, 'Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p,p′-DDT among preschoolers', Environmental Health Perspectives, vol. 116, no. 11, pp. 1581-1585. https://doi.org/10.1289/ehp.11303
Morales, Eva ; Sunyer, Jordi ; Castro-Giner, Francesc ; Estivill, Xavier P. ; Julvez, Jordi ; Ribas-Fitó, Nuria ; Torrent, Maties ; Grimalt, Joan O. ; de Cid, Rafael. / Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p,p′-DDT among preschoolers. In: Environmental Health Perspectives. 2008 ; Vol. 116, No. 11. pp. 1581-1585.
@article{c247ee12359c409db2611db2562f14cc,
title = "Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p,p′-DDT among preschoolers",
abstract = "Background: Early-life exposure to p,p'-DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] is associated with a decrease in cognitive skills among preschoolers at 4 years of age. We hypothesized that genetic variability in glutathione S-transferase (GST) genes (GSTP1, GSTM1, and GSTT1) could influence the effects of prenatal exposure to p,p'-DDT. Methods: We used data from 326 children assessed in a prospective population-based birth cohort at the age of 4 years. In that study, the McCarthy Scales of Children's Abilities were administrated by psychologists, organochlorine compounds were measured in cord serum, and genotyping was conducted for the coding variant Ile105Val from GSTP1 and for null alleles from GSTM1 and GSTT1. We used linear regression models to measure the association between organochlorines and neurodevelopmental scores by GST polymorphisms. Results: p,p'-DDT cord serum concentration was inversely associated with general cognitive, memory, quantitative, and verbal skills, as well as executive function and working memory, in children who had any GSTP1 Val-105 allele. GSTP1 polymorphisms and prenatal p,p'-DDT exposure showed a statistically significant interaction for general cognitive skills (p = 0.05), quantitative skills (p = 0.02), executive function (p = 0.01), and working memory (p = 0.02). There were no significant associations between p,p'-DDT and cognitive functioning at 4 years of age according to GSTM1 and GSTT1 polymorphisms. Conclusions: Results indicate that children with GSTP1 Val-105 allele were at higher risk of the adverse cognitive functioning effects of prenatal p,p'-DDT exposure.",
keywords = "Children, Cognitive functioning, Gene-environment interaction, Glutathione S-transferase, Neurodevelopment, p,p′-DDE, p,p′-DDT, Polymorphism",
author = "Eva Morales and Jordi Sunyer and Francesc Castro-Giner and Estivill, {Xavier P.} and Jordi Julvez and Nuria Ribas-Fit{\'o} and Maties Torrent and Grimalt, {Joan O.} and {de Cid}, Rafael",
year = "2008",
doi = "10.1289/ehp.11303",
language = "English",
volume = "116",
pages = "1581--1585",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "11",

}

TY - JOUR

T1 - Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p,p′-DDT among preschoolers

AU - Morales, Eva

AU - Sunyer, Jordi

AU - Castro-Giner, Francesc

AU - Estivill, Xavier P.

AU - Julvez, Jordi

AU - Ribas-Fitó, Nuria

AU - Torrent, Maties

AU - Grimalt, Joan O.

AU - de Cid, Rafael

PY - 2008

Y1 - 2008

N2 - Background: Early-life exposure to p,p'-DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] is associated with a decrease in cognitive skills among preschoolers at 4 years of age. We hypothesized that genetic variability in glutathione S-transferase (GST) genes (GSTP1, GSTM1, and GSTT1) could influence the effects of prenatal exposure to p,p'-DDT. Methods: We used data from 326 children assessed in a prospective population-based birth cohort at the age of 4 years. In that study, the McCarthy Scales of Children's Abilities were administrated by psychologists, organochlorine compounds were measured in cord serum, and genotyping was conducted for the coding variant Ile105Val from GSTP1 and for null alleles from GSTM1 and GSTT1. We used linear regression models to measure the association between organochlorines and neurodevelopmental scores by GST polymorphisms. Results: p,p'-DDT cord serum concentration was inversely associated with general cognitive, memory, quantitative, and verbal skills, as well as executive function and working memory, in children who had any GSTP1 Val-105 allele. GSTP1 polymorphisms and prenatal p,p'-DDT exposure showed a statistically significant interaction for general cognitive skills (p = 0.05), quantitative skills (p = 0.02), executive function (p = 0.01), and working memory (p = 0.02). There were no significant associations between p,p'-DDT and cognitive functioning at 4 years of age according to GSTM1 and GSTT1 polymorphisms. Conclusions: Results indicate that children with GSTP1 Val-105 allele were at higher risk of the adverse cognitive functioning effects of prenatal p,p'-DDT exposure.

AB - Background: Early-life exposure to p,p'-DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] is associated with a decrease in cognitive skills among preschoolers at 4 years of age. We hypothesized that genetic variability in glutathione S-transferase (GST) genes (GSTP1, GSTM1, and GSTT1) could influence the effects of prenatal exposure to p,p'-DDT. Methods: We used data from 326 children assessed in a prospective population-based birth cohort at the age of 4 years. In that study, the McCarthy Scales of Children's Abilities were administrated by psychologists, organochlorine compounds were measured in cord serum, and genotyping was conducted for the coding variant Ile105Val from GSTP1 and for null alleles from GSTM1 and GSTT1. We used linear regression models to measure the association between organochlorines and neurodevelopmental scores by GST polymorphisms. Results: p,p'-DDT cord serum concentration was inversely associated with general cognitive, memory, quantitative, and verbal skills, as well as executive function and working memory, in children who had any GSTP1 Val-105 allele. GSTP1 polymorphisms and prenatal p,p'-DDT exposure showed a statistically significant interaction for general cognitive skills (p = 0.05), quantitative skills (p = 0.02), executive function (p = 0.01), and working memory (p = 0.02). There were no significant associations between p,p'-DDT and cognitive functioning at 4 years of age according to GSTM1 and GSTT1 polymorphisms. Conclusions: Results indicate that children with GSTP1 Val-105 allele were at higher risk of the adverse cognitive functioning effects of prenatal p,p'-DDT exposure.

KW - Children

KW - Cognitive functioning

KW - Gene-environment interaction

KW - Glutathione S-transferase

KW - Neurodevelopment

KW - p,p′-DDE

KW - p,p′-DDT

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=58849149430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849149430&partnerID=8YFLogxK

U2 - 10.1289/ehp.11303

DO - 10.1289/ehp.11303

M3 - Article

C2 - 19057715

AN - SCOPUS:58849149430

VL - 116

SP - 1581

EP - 1585

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 11

ER -