Influence of coinfecting pathogens on HIV expression: Evidence for a role of Toll-like receptors

André Báfica, Charles A. Scanga, Marco Schito, Damien J. Chaussabel, Alan Sher

Research output: Contribution to journalShort survey

75 Citations (Scopus)

Abstract

Immune activation of HIV gene expression as a consequence of the host response to coinfecting pathogens has been implicated as an important factor in AIDS progression. Immune responsiveness to many of the infectious agents associated with HIV has been demonstrated to depend on a family of innate recognition molecules, known as Toll-like receptors (TLR). Therefore, TLR-pathogen interactions could play an indirect role in regulating HIV-associated disease. In this review, we summarize emerging evidence for the influence of TLR recognition on HIV gene activation and AIDS progression.

Original languageEnglish
Pages (from-to)7229-7234
Number of pages6
JournalJournal of Immunology
Volume172
Issue number12
Publication statusPublished - 15 Jun 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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