Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions.

Jessica Matta, Myriam Baratin, Laurent Chiche, Jean Marie Forel, Céline Cognet, Guillemette Thomas, Catherine Farnarier, Christelle Piperoglou, Laurent Papazian, Damien J. Chaussabel, Sophie Ugolini, Frédéric Vély, Eric Vivier

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

B7-H6, a member of the B7 family of immunoreceptors, is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. B7-H6 is not detected in normal human tissues at steady state but is expressed on tumor cells. However, whether B7-H6 can be expressed in other conditions remains unknown. We analyzed here the pathways that lead to the expression of B7-H6 in nontransformed cells. In vitro, B7-H6 was induced at the surface of CD14(+)CD16(+) proinflammatory monocytes and neutrophils upon stimulation by ligands of Toll-like receptors or proinflammatory cytokines such as interleukin-1β and tumor necrosis factor α. In these conditions, a soluble form of B7-H6 (sB7-H6) was also produced by activated monocytes and neutrophils. In vivo, B7-H6 was expressed on circulating proinflammatory CD14(+)CD16(+) monocytes in a group of patients in sepsis conditions, and was linked to an increased mortality. sB7-H6 was selectively detected in the sera of patients with gram-negative sepsis and was associated with membrane vesicles that co-sedimented with the exosomal fraction. These findings reveal that B7-H6 is not only implicated in tumor immunosurveillance but also participates in the inflammatory response in infectious conditions.

Original languageEnglish
Pages (from-to)394-404
Number of pages11
JournalBlood
Volume122
Issue number3
DOIs
Publication statusPublished - 18 Jul 2013
Externally publishedYes

Fingerprint

Natural Killer Cell Receptors
Tumors
Monocytes
Ligands
Natural Cytotoxicity Triggering Receptor 3
Toll-Like Receptors
Sepsis
Neutrophils
Interleukin-1
Immunologic Monitoring
Tumor Necrosis Factor-alpha
Cells
Tissue
Cytokines
Membranes
Natural Killer Cells
Neoplasms
Mortality
Serum

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Matta, J., Baratin, M., Chiche, L., Forel, J. M., Cognet, C., Thomas, G., ... Vivier, E. (2013). Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. Blood, 122(3), 394-404. https://doi.org/10.1182/blood-2013-01-481705

Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. / Matta, Jessica; Baratin, Myriam; Chiche, Laurent; Forel, Jean Marie; Cognet, Céline; Thomas, Guillemette; Farnarier, Catherine; Piperoglou, Christelle; Papazian, Laurent; Chaussabel, Damien J.; Ugolini, Sophie; Vély, Frédéric; Vivier, Eric.

In: Blood, Vol. 122, No. 3, 18.07.2013, p. 394-404.

Research output: Contribution to journalArticle

Matta, J, Baratin, M, Chiche, L, Forel, JM, Cognet, C, Thomas, G, Farnarier, C, Piperoglou, C, Papazian, L, Chaussabel, DJ, Ugolini, S, Vély, F & Vivier, E 2013, 'Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions.', Blood, vol. 122, no. 3, pp. 394-404. https://doi.org/10.1182/blood-2013-01-481705
Matta, Jessica ; Baratin, Myriam ; Chiche, Laurent ; Forel, Jean Marie ; Cognet, Céline ; Thomas, Guillemette ; Farnarier, Catherine ; Piperoglou, Christelle ; Papazian, Laurent ; Chaussabel, Damien J. ; Ugolini, Sophie ; Vély, Frédéric ; Vivier, Eric. / Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. In: Blood. 2013 ; Vol. 122, No. 3. pp. 394-404.
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