Individual chromosomes as viscoelastic copolymers

S. Almagro, S. Dimitrov, T. Hirano, M. Vallade, D. Riveline

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report elastic measurements of individual chromosomes observed in vitro. Free fluctuations of shapes show that a chromosome can be seen as a copolymer, exhibiting rigid regions alternating with semi-flexible regions. We characterize this behavior and compare it with known biopolymers. We further show that the inner part of a chromosome exhibits viscoelasticity, as extracted by the loading rate dependence of the stretch modulus. Taken together, these data suggest an organization for the chromosome as a copolymer composed of an inner rigid core exhibiting viscoelasticity surrounded by an elastic soft envelope.

Original languageEnglish
Pages (from-to)908-914
Number of pages7
JournalEurophysics Letters
Volume63
Issue number6
DOIs
Publication statusPublished - Sep 2003
Externally publishedYes

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chromosomes
copolymers
viscoelasticity
loading rate
biopolymers
envelopes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Individual chromosomes as viscoelastic copolymers. / Almagro, S.; Dimitrov, S.; Hirano, T.; Vallade, M.; Riveline, D.

In: Europhysics Letters, Vol. 63, No. 6, 09.2003, p. 908-914.

Research output: Contribution to journalArticle

Almagro, S, Dimitrov, S, Hirano, T, Vallade, M & Riveline, D 2003, 'Individual chromosomes as viscoelastic copolymers', Europhysics Letters, vol. 63, no. 6, pp. 908-914. https://doi.org/10.1209/epl/i2003-00609-3
Almagro, S. ; Dimitrov, S. ; Hirano, T. ; Vallade, M. ; Riveline, D. / Individual chromosomes as viscoelastic copolymers. In: Europhysics Letters. 2003 ; Vol. 63, No. 6. pp. 908-914.
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