Increased levels of granulocytic myeloid-derived suppressor cells in peripheral blood and tumour tissue of pancreatic cancer patients

Yazan S. Khaled, Basil J. Ammori, Eyad Elkord

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Pancreatic cancer (PC) often presents late with poor survival. While role of immunosuppressive cells in preclinical studies provided help to develop immunotherapeutic agents, these cells remain under investigation in PC. The aim of this study was to characterise the different subsets of myeloid-derived suppressor cells (MDSCs) and evaluate their level and function in the circulation and tissue of PC patients. Significant increases in circulating and tumour-infiltrating granulocytic (Lin-HLA-DR-CD33+CD11b+CD15+), but not monocytic (Lin-HLA-DR-CD14+), MDSCs were detected in PC patients when compared with healthy donors and patients with chronic pancreatitis. The circulating MDSCs from PC patients expressed arginase 1, which represents their functional state. Blood levels of MDSCs showed no association with PC stage or preoperative levels of tumour markers. These findings provide a first characterisation of the phenotype of different subsets of peripheral and local MDSCs in PC patients and suggest that the frequency and contribution of these cells are predominantly granulocytic. This information demonstrates that MDSCs play a role in pancreatic cancer and future large validation studies may help in the development of new immunotherapeutic strategies to inhibit or eliminate MDSC function.

Original languageEnglish
Pages (from-to)879897
Number of pages1
JournalJournal of Immunology Research
Volume2014
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Pancreatic Neoplasms
Neoplasms
HLA-DR Antigens
Arginase
Myeloid-Derived Suppressor Cells
Validation Studies
Chronic Pancreatitis
Immunosuppressive Agents
Tumor Biomarkers
Tissue Donors
Phenotype
Survival

ASJC Scopus subject areas

  • Medicine(all)

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Increased levels of granulocytic myeloid-derived suppressor cells in peripheral blood and tumour tissue of pancreatic cancer patients. / Khaled, Yazan S.; Ammori, Basil J.; Elkord, Eyad.

In: Journal of Immunology Research, Vol. 2014, 2014, p. 879897.

Research output: Contribution to journalArticle

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