Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease

Nour Majbour, Davide Chiasserini, Nishant Vaikath, Paolo Eusebi, Takahiko Tokuda, Wilma Van De Berg, Lucilla Parnetti, Paolo Calabresi, Omar Ali El-Agnaf

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Abstract

Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer's disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measured CSF levels of different α-syn species in a cohort of AD patients (n = 225) who showed a CSF profile typical of AD at baseline as well as in cognitively intact controls (n = 68). CSF total α-syn (t-α-syn) significantly increased in the AD group (p < 0.0001) compared to controls, while oligomeric- and phosphorylated-Ser129-α-syn did not change significantly. ROC analysis showed a sensitivity of 85% and a specificity of 84% (AUC = 0.88) in distinguishing AD from controls. T-α-syn levels correlated positively with tau species in AD group and negatively with baseline MMSE score. Our data support the added value of measurement of CSF α-syn species for further characterization of the CSF AD profile.

Original languageEnglish
Article number40263
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 10 Jan 2017

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alpha-Synuclein
Alzheimer Disease
ROC Curve
Area Under Curve
Biomarkers
Sensitivity and Specificity

ASJC Scopus subject areas

  • General

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Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease. / Majbour, Nour; Chiasserini, Davide; Vaikath, Nishant; Eusebi, Paolo; Tokuda, Takahiko; Van De Berg, Wilma; Parnetti, Lucilla; Calabresi, Paolo; Ali El-Agnaf, Omar.

In: Scientific Reports, Vol. 7, 40263, 10.01.2017.

Research output: Contribution to journalArticle

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AU - Chiasserini, Davide

AU - Vaikath, Nishant

AU - Eusebi, Paolo

AU - Tokuda, Takahiko

AU - Van De Berg, Wilma

AU - Parnetti, Lucilla

AU - Calabresi, Paolo

AU - Ali El-Agnaf, Omar

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